TABLE 2.

Brain volumes at baseline and atrophy rates over time in patients and healthy controls

	Alzheimer's disease	Healthy volunteers (UCL)	Traumatic brain injury	Healthy volunteers (ICL, TBI age‐matched)	Healthy volunteers (ICL, AD age‐matched)
Baseline volume, median (IQR)
Gray matter	0.38 (0.04)	0.44 (0.04)	0.45 (0.04)	0.48 (0.02)	0.43 (0.04)
White matter	0.29 (0.03)	0.31 (0.02)	0.31 (0.03)	0.33 (0.02)	0.32 (0.02)
Whole brain	0.67 (0.05)	0.76 (0.06)	0.76 (0.05)	0.81 (0.05)	0.75 (0.03)
CSF	0.33 (0.05)	0.24 (0.06)	0.24 (0.05)	0.19 (0.05)	0.25 (0.03)
JD percentage brain volume change rate, median (IQR)
Gray matter	−0.8 (0.8)	−0.2 (0.2)	−0.2 (0.5)	0.0 (0.5)	0.0 (0.4)
White matter	−0.9 (0.9)	−0.2 (0.3)	−0.3 (0.7)	0.1 (0.7)	−0.4 (0.6)
Whole brain	−0.9 (0.9)	−0.2 (0.3)	−0.3 (0.5)	0.1 (0.6)	−0.2 (0.4)
CSF	1.0 (0.7)	0.3 (0.3)	0.4 (0.9)	0.3 (0.6)	0.9 (0.4)

Abbreviations: ICV, intracranial volume; JD, Jacobian determinant atrophy rate.