Table 2.

Comparison of each blood biomarker of unipolar and bipolar depression between the two groups.

Biomarker	Unipolar depression	Bipolar depression	p_t	p_b
WBC	5.87 ± 1.59	6.67 ± 2.01	<0.001	<0.001
PLR	121.99 ± 46.76	111.24 ± 43.52	<0.001	<0.001
MONO	0.46 ± 0.15	0.52 ± 0.18	<0.001	<0.001
Albumin	40.77 ± 3.47	41.94 ± 4.11	<0.001	<0.001
LDL	2.47 ± 0.79	2.69 ± 0.88	<0.001	<0.001
Potassium	4.00 ± 0.33	4.07 ± 0.31	<0.001	<0.001

Two sets of p-values are reported: p_t is obtained from T-tests; p_b is obtained from Tests of between-subjects effects with each blood biomarker as dependent variable and clinical variables as covariates. Statistically significant differences are observed for each blood biomarker between the two groups, regardless of whether clinical variables are considered as covariates. This demonstrates the independent ability of each biomarker to differentiate between unipolar and bipolar depression.