Table 1.
Baseline characteristics in participants with acute ischaemic stroke
| All | GTN | Sham | |
| Participants | 597 | 302 | 295 |
| Ambulance data | |||
| Age (years) | 75 (12) | 74 (13) | 76 (12) |
| Sex, female (%) | 287 (48) | 146 (48) | 141 (48) |
| Time (min) | |||
| OTR | 67 [45,108] | 66 [44,105] | 67 [45,110] |
| <1 hour (%) | 257 (43) | 138 (46) | 119 (40) |
| 1–2 hours (%) | 214 (36) | 101 (33) | 113 (38) |
| >2 hours (%) | 126 (21) | 63 (21) | 63 (21) |
| ECG, AF/flutter (%) | 127 (26) | 60 (25) | 67 (27) |
| Systolic BP (mm Hg) | 161 (23) | 161 (24) | 160 (23) |
| Diastolic BP (mm Hg) | 90 (17) | 91 (18) | 89 (16) |
| Heart rate (bpm) | 83 (20) | 83 (20) | 83 (20) |
| GCS (/15) | 14 (2) | 14 (2) | 14 (2) |
| <14 (%) | 174 (29) | 90 (30) | 84 (28) |
| FAST (/3) | 3 (0) | 3 (0) | 3 (0) |
| =3 (%) | 391 (65) | 195 (65) | 196 (66) |
| Hospital admission | |||
| Time (min) | |||
| RTH | 24 [17,34] | 23 [16,34] | 25 [17,34] |
| RTI | 55 [42,75] | 55 [41,76] | 56 [42,74] |
| Ethnicity, non-white (%) | 54 (9) | 23 (8) | 31 (11) |
| Premorbid mRS>2 (%) | 107 (18) | 54 (18) | 53 (18) |
| Medical history (%) | |||
| Hypertension | 355 (59) | 176 (58) | 179 (61) |
| Diabetes mellitus | 125 (21) | 59 (20) | 66 (22) |
| Previous stroke | 137 (23) | 78 (26) | 59 (20) |
| IHD | 103 (17) | 47 (16) | 56 (19) |
| Smoking, current | 90 (18) | 54 (21) | 36 (14) |
| Alcohol, >12 upw | 38 (8) | 17 (7) | 21 (9) |
| Antithrombotic | |||
| Antiplatelet therapy | 139 (34) | 68 (34) | 71 (35) |
| Oral anticoagulation | 38 (10) | 16 (8) | 22 (11) |
| Reperfusion (%) | |||
| Alteplase (%) | 284 (48) | 150 (50) | 134 (45) |
| Intra-arterial (%) | 24 (4) | 7 (2) | 17 (6) |
| Carotid stenosis, ipsilateral (%) | |||
| <50% | 217 (79) | 116 (82) | 101 (77) |
| 50%–70% | 28 (10) | 15 (11) | 13 (10) |
| >70% | 14 (5) | 8 (6) | 6 (5) |
| >50% bilateral | 3 (1) | 2 (1) | 1 (1) |
Data are number (%), median [IQR] or mean (SD).
AF, atrial fibrillation; BP, blood pressure; FAST, Face-Arm-Speech-Time; GCS, Glasgow Coma Scale; IHD, ischaemic heart disease; mRS, modified Rankin Scale; OTR, onset to randomisation; RTH, randomisation to hospital; RTI, randomisation to imaging; upw, units per week.