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. 2024 Mar 13;27(5):206. doi: 10.3892/ol.2024.14339

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Copyright: © 2024 Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — GBM prognosis may be associated with P-NPCs. (A) Heatmap of gene expression differences between negative-cells and P-NPCs. (B) ssGSEA score of P-NPCs in the Chinese Glioma Genome Atlas database across various grades of glioma (***P<0.001, with independent t-test). (C) The ssGSEA score of P-NPCs derived from both normal and GBM patient samples in The Cancer Genome Atlas database (****P<0.0001, with independent t-test). (D) Suitability of P-NPCs and CCNA2 and NEK2 expression in glioma grades. (E) Association of high expression of marker genes with shorter overall survival in patients with glioma, according to the Kaplan-Meier analysis (P<0.0001 for WHO II, P<0.0001 for WHO III and P=0.0017 for WHO IV, respectively, with log-rank test). GBM, glioblastoma; P-NPCs; positive neural progenitor cells; ssGSEA, single-sample gene set enrichment analysis; CCNA2, cyclin A2; NEK2, NIMA related kinase 2; WHO, World Health Organization.