Figure 7.

Activation of the G2M checkpoint pathway in positive neural progenitor cells. (A) Hallmark pathways, including mTORC1, hypoxia, Myc-targets-v1, TNFα-signaling-via-NF-κB and G2M checkpoint, were enriched. (B) Four pathways (mTORC1, cell cycle, oxidative and NF-κB) were selected for butterfly plots based on cluster enrichment scores. (C) Cluster 3 had enriched pathways, including mitotic spindle and G2M checkpoint, as compared with cluster 4. (D) Tricycle analysis of the cell cycle position of single-cell data. GBM, glioblastoma; t-SNE, t-distributed stochastic neighbor embedding; NES, normalized enrichment score.