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. 2024 Mar 21;4(3):861–875. doi: 10.1158/2767-9764.CRC-22-0366

FIGURE 4.

FIGURE 4

CD163+ TAMs are associated with lymphogenesis. A, LVD and LVI were assessed in the stroma using D2-40–stained lymphatic endothelium. Intratumoral and stromal CD163 immunoreactivity was recorded as in Fig. 1B; data are presented as mean immunoreactivity normalized to tissue compartments in percent. CD163+ TAMs were categorized on the basis of high/low LVD and the presence/absence of LVI. Individual datapoints, shown as dots, overlap summary statistics boxplots with medians represented by horizontal center lines. Significance analysis by two-sided Mann–Whitney U test with Benjamini–Hochberg procedure. B, BVD and BVI were assessed in the stroma using CD31-stained vessels. Intratumoral and stromal CD163 immunoreactivity was recorded as in Fig. 1B; data are presented as mean immunoreactivity normalized to tissue compartments in percent. CD163+ TAMs were categorized on the basis of high/low BVD and the presence/absence of BVI. Individual datapoints, shown as dots, overlap summary statistics boxplots with medians represented by horizontal center lines. Significance analysis by two-sided Mann–Whitney U test with Benjamini–Hochberg procedure.