. 2024 Mar 21;4(3):861–875. doi: 10.1158/2767-9764.CRC-22-0366

TABLE 1.

Density of stromal TAMs affect outcome. Survival analysis of intratumoral and stromal immune cell counts

	Recurrence-free survival
	Univariate analysis			Multivariate analysis^a
Variable	HR	95% CI	P-value	HR	95% CI	P-value
Intratumoral CD163⁺ TAMs (high vs. low)	2.2	0.93–5.32	0.07
Stromal CD163⁺ TAMs (high vs. low)	4.4	1.69–11.35	0.001	3.5	1.28–9.63	0.02
Lymph node involvement (present vs. absent)	2.9	1.26–6.86	0.01	1.89	0.77–4.62	0.2
	Overall survival
	Univariate analysis			Multivariate analysis ^a
Variable	HR	95% CI	P-value	HR	95% CI	P-value
Intratumoral CD163⁺ TAMs (high vs. low)	2.2	0.92–5.3	0.07
Stromal CD163⁺ TAMs (high vs. low)	2.9	1.2–7.28	0.02	2.3	0.9–5.84	0.09
Lymph node involvement (present vs. absent)	3.7	1.57–8.57	0.003	2.95	1.2–7.1	0.02

Abbreviations: CI, confidence interval; HR, hazard ratio.

^aOnly variables significantly associated in the univariate analysis were included in the multivariate analysis.