TABLE 2.
Stromal TAMs indicate aggressive tumor biology. Association between intratumoral and stromal immune cell counts and clinicopathologic parameters
| Intratumoral | Stromal | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | High | Low | P-value | q-value | High | Low | P-value | q-value | |
| CD163+ TAMs (n = 49) | |||||||||
| Tumor stage (TNM) | pT2, pT3 | 15 | 12 | 0.57 | 1 | 19 | 8 | 0.0014 | 0.04 |
| pT1 | 10 | 12 | 5 | 17 | |||||
| Tumor stage (FIGO) | II, III, IV | 18 | 12 | 0.15 | 1 | 22 | 8 | 0.00002 | 0.001 |
| I | 7 | 12 | 2 | 17 | |||||
| Tumor grade | 2, 3 | 25 | 20 | 0.05 | 0.63 | 22 | 23 | 1 | 1 |
| 1 | 0 | 4 | 2 | 2 | |||||
| Lymph node involvement | Present | 12 | 5 | 0.07 | 0.7 | 13 | 4 | 0.007 | 0.1 |
| Absent | 13 | 19 | 11 | 21 | |||||
| Metastasis | Present | 2 | 1 | 1 | 1 | 2 | 1 | 0.61 | 1 |
| Absent | 23 | 23 | 22 | 24 | |||||
| CD3+ T cells (n = 41) | |||||||||
| Tumor stage (TNM) | pT2, pT3 | 11 | 12 | 0.76 | 1 | 10 | 13 | 0.35 | 1 |
| pT1 | 10 | 8 | 11 | 7 | |||||
| Tumor stage (FIGO) | II, III, IV | 13 | 13 | 1 | 1 | 13 | 13 | 1 | 1 |
| I | 8 | 7 | 8 | 7 | |||||
| Tumor grade | 2, 3 | 19 | 18 | 1 | 1 | 18 | 19 | 0.61 | 1 |
| 1 | 2 | 2 | 3 | 1 | |||||
| Lymph node involvement | Present | 7 | 9 | 0.53 | 1 | 7 | 9 | 0.53 | 1 |
| Absent | 14 | 11 | 14 | 11 | |||||
| Metastasis | Present | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 |
| Absent | 19 | 19 | 19 | 19 | |||||
| CD20+ B cells (n = 43) | |||||||||
| Tumor stage (TNM) | pT2, pT3 | 1 | 24 | 1 | 1 | 11 | 14 | 0.2 | 1 |
| pT1 | 1 | 17 | 12 | 6 | |||||
| Tumor stage (FIGO) | II, III, IV | 2 | 26 | 0.53 | 1 | 14 | 14 | 0.75 | 1 |
| I | 0 | 15 | 9 | 6 | |||||
| Tumor grade | 2, 3 | 2 | 37 | 1 | 1 | 21 | 18 | 1 | 1 |
| 1 | 0 | 4 | 2 | 2 | |||||
| Lymph node involvement | Present | 1 | 15 | 1 | 1 | 7 | 9 | 0.36 | 1 |
| Absent | 1 | 26 | 16 | 11 | |||||
| Metastasis | Present | 0 | 3 | 1 | 1 | 1 | 18 | 0.59 | 1 |
| Absent | 2 | 38 | 22 | 2 | |||||
| CD68+ macrophages (n = 42) | |||||||||
| Tumor stage (TNM) | pT2, pT3 | 13 | 11 | 0.76 | 1 | 12 | 12 | 1 | 1 |
| pT1 | 8 | 10 | 9 | 9 | |||||
| Tumor stage (FIGO) | II, III, IV | 15 | 12 | 0.52 | 1 | 14 | 13 | 1 | 1 |
| I | 6 | 9 | 7 | 8 | |||||
| Tumor grade | 2, 3 | 20 | 18 | 0.61 | 1 | 18 | 20 | 0.61 | 1 |
| 1 | 1 | 3 | 3 | 1 | |||||
| Lymph node involvement | Present | 9 | 7 | 0.75 | 1 | 8 | 8 | 1 | 1 |
| Absent | 12 | 14 | 13 | 13 | |||||
| Metastasis | Present | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 |
| Absent | 19 | 20 | 19 | 20 | |||||
| Foxp3+ T cells (n = 49) | |||||||||
| Tumor stage (TNM) | pT2, pT3 | 14 | 13 | 0.78 | 1 | 14 | 13 | 1 | 1 |
| pT1 | 10 | 12 | 11 | 11 | |||||
| Tumor stage (FIGO) | II, III, IV | 16 | 14 | 0.56 | 1 | 17 | 13 | 0.39 | 1 |
| I | 8 | 11 | 8 | 11 | |||||
| Tumor grade | 2, 3 | 23 | 22 | 0.61 | 1 | 22 | 23 | 0.61 | 1 |
| 1 | 1 | 3 | 3 | 1 | |||||
| Lymph node involvement | Present | 11 | 6 | 0.14 | 1 | 10 | 7 | 0.55 | 1 |
| Absent | 13 | 19 | 15 | 17 | |||||
| Metastasis | Present | 1 | 2 | 1 | 1 | 1 | 2 | 0.61 | 1 |
| Absent | 23 | 23 | 24 | 22 | |||||