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. 2024 Feb 16;81(4):876–886. doi: 10.1161/HYPERTENSIONAHA.123.22292

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© 2024 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Isolation of syncytiotrophoblast extracellular vesicles (STB-EVs) from venous plasma. A, Diagram summarizing protocol for STB-EV isolation: plasma preparation, 10 000g centrifugation to isolate medium-large extracellular vesicles (MLEVs), immuno-isolation using magnetic beads coated with antibody to placental alkaline phosphatase (NDOG2). B, Relative expression of miR518 in EVs isolated from 3 samples using above technique (from left to right: pregnant plasma using beads coated with NDOG2; nonpregnant plasma spiked with perfusion STB-EVs using beads coated with NDOG2; pregnant plasma using beads without NDOG2 coating). Bars represent median, error bars represent interquartile range. C, Relative expression of 5′-tRF-Glu-CTC (tRF-A) in perfusion-derived STB-EVs (not gestation-matched, reproduced from Figure 2B for comparison) and gestation-matched peripheral venous plasma STB-EVs from women with early onset preeclampsia (n=14) and normotensive pregnancies (n=12).