Table 2.

Results of heterogeneity and horizontal pleiotropy.

Gut microbiota	Heterogeneity test		MR-PRESSO		MR-Egger
	Q-P (MR Egger)	Q-P (IVW)	MR-PRESSO global test	Outlier-corrected	Egger intercept test
Phylum Tenericutes	0.714	0.780	0.806	NA	0.745
Class Deltaproteobacteria	0.968	0.976	0.987	NA	0.607
Class Mollicutes	0.714	0.780	0.782	NA	0.745
Family Desulfovibrionaceae	0.934	0.945	0.984	NA	0.542
Family Enterobacteriaceae	0.555	0.642	0.34	NA	0.608
Family Streptococcaceae	0.619	0.693	0.557	NA	0.690
Order Desulfovibrionales	0.965	0.949	0.962	NA	0.352
Order Enterobacteriales	0.555	0.642	0.327	NA	0.608
genus Hungatella	0.760	0.876	0.902	NA	0.849
Genus Senegalimassilia	0.570	0.499	0.539	NA	0.329
Genus Streptococcus	0.849	0.864	0.733	NA	0.477

IVW = inverse variance weighted, MR-PRESSO = MR pleiotropy residual sum and outlier.