Table 2.
Multiple Logistic Regression Analysis of More Aggressive compared to Less Aggressive Prostate Cancer Cases at Diagnosis
| All Cases (N=57,885: 20,481 More Aggressive; 37,404 Less Aggressive) | White Cases (N=50,640: 17,676 More Aggressive; 32,964 Less Aggressive) | Black Cases (N=6,568: 2,547 More Aggressive; 4,021 Less Aggressive) | |
|---|---|---|---|
| Variables | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Age at Diagnosis in Years A | 1.03 (1.03, 1.03) | 1.03 (1.03, 1.04) | 1.02 (1.01, 1.02) |
| Serum PSAA (ng/mL) | 1.03 (1.03, 1.03) | 1.03 (1.03, 1.03) | 1.03 (1.03, 1.03) |
| Race | |||
| White | Reference | ------------------- | ------------------- |
| Black | 1.14 (1.07, 1.21) | ------------------- | ------------------- |
| Other | 1.13 (0.96, 1.34) | ------------------- | ------------------- |
| Ethnicity | |||
| Non-Hispanic | Reference | Reference | Reference |
| Hispanic | 1.01 (0.87, 1.17) | 1.07 (0.91, 1.26) | 0.60 (0.30, 1.15) |
| Insurance | |||
| Insured | Reference | Reference | Reference |
| Uninsured | 1.65 (1.29, 2.10) | 1.65 (1.26, 2.16) | 1.69 (0.93, 3.08) |
| Lymph Node Positive | |||
| No | Reference | Reference | Reference |
| Yes | 22.69 (18.45, 28.25) | 23.76 (18.97, 30.19) | 16.54 (9.84, 30.15) |
| Geographical Region | |||
| Urban Non-Appalachia | Reference | Reference | Reference |
| Rural Appalachia | 0.92 (0.87, 0.97) | 0.92 (0.86, 0.97) | 0.86 (0.54, 1.33) |
| Urban Appalachia | 1.12 (1.08, 1.17) | 1.12 (1.07, 1.17) | 1.18 (1.03, 1.35) |
| Year at Diagnosis | |||
| 2004 | Reference | Reference | Reference |
| 2005 | 0.77 (0.63, 0.94) | 0.79 (0.64, 0.99) | 0.62 (0.36, 1.07) |
| 2006 | 0.76 (0.63, 0.92) | 0.79 (0.64, 0.97) | 0.60 (0.36, 1.01) |
| 2007 | 0.73 (0.61, 0.89) | 0.76 (0.61, 0.93) | 0.60 (0.36, 1.01) |
| 2008 | 0.75 (0.62, 0.90) | 0.75 (0.61, 0.93) | 0.71 (0.43, 1.19) |
| 2009 | 0.82 (0.68, 0.99) | 0.82 (0.67, 1.02) | 0.76 (0.45, 1.27) |
| 2010 | 0.87 (0.72, 1.05) | 0.90 (0.73, 1.11) | 0.68 (0.41, 1.15) |
| 2011 | 0.93 (0.77, 1.13) | 0.93 (0.76, 1.15) | 0.88 (0.53, 1.48) |
| 2012 | 0.97 (0.80, 1.18) | 1.01 (0.82, 1.25) | 0.77 (0.47, 1.30) |
| 2013 | 1.10 (0.91, 1.34) | 1.14 (0.93, 1.41) | 0.85 (0.51, 1.43) |
| 2014 | 1.27 (1.05, 1.54) | 1.32 (1.07, 1.63) | 0.98 (0.59, 1.63) |
Note: OR = odds ratio; CI = confidence interval; PSA = prostate-specific antigen
A
= one unit increase; “All Cases” include other races and therefore the total number of all cases is greater than the sum of black and white cases; and, Unknown/missing values for the study variables were removed from the analysis.