Liraglutide 3.0: Cannot take this if history of suicide attempts or suicidal ideations, alcohol misuse disorder, triglycerides > 1000 mg/dL, or gallstones with intact gallbladder. Can cause nausea, vomiting, diarrhea, constipation, and headache. Risk for pancreatitis, renal failure; contraindicated if patient or family history of MEN2 or medullary thyroid cancer. Lorcaserin: Multiple medications interact with lorcaserin, the primary offenders include metoprolol, tramadol, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors. Persons aged 65 years and over were not in studies in large-scale trials, given lack of representation; caution is advised when treating older adults with lorcaserin. Can cause hypoglycemia, headache, fatigue. Has also been seen to cause serotonin syndrome, suicidal ideation, heart valve disorder, and bradycardia. Phentermine-topiramate ER: Cannot be used with hyperthyroidism, glaucoma, end-stage renal disease, hepatic dysfunction, cholelithiasis in < 6 months, kidney stones, recurrent major depressive disorder, moderate to severe depression, tramadol, topiramate, monoamine oxidase inhibitors, carbonic anhydrase inhibitors. Naltrexone/bupropion sustained release: Cannot be used in history of uncontrolled hypertension, seizure disorder, bulimia, anorexia, concurrent opioid use, or use of opioids within the past 7-10 days. Excluded for those undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs. Concurrent use of naltrexone or bupropion. No concurrent use of a CYP2B6 inducer (ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, and phenytoin). Orlistat: Cannot be used with history of chronic malabsorption syndrome, chronic diarrhea, cholestasis, or kidney stones.
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