Appendix 1—table 1. P. falciparum human model parameter values.

Full details can be found in the original publication (Griffin et al., 2016), including references for parameters and intervals for the prior and posterior distributions (median values of the posterior distribution are used in model simulations).

Parameter	Symbol	Estimate
Human infection duration (days)
Latent period	${\displaystyle d_E}$	12
Patent infection	${\displaystyle \frac{1}{r_A}}$	195
Clinical disease (untreated)	${\displaystyle \frac{1}{r_D}}$	5
Treatment of clinical disease	${\displaystyle \frac{1}{r_T}}$	5
Sub-patent infection	${\displaystyle \frac{1}{r_U}}$	110.299
Prophylaxis	${\displaystyle \frac{1}{r_P}}$	15
Age and heterogeneity
Age-dependent biting parameter	${\displaystyle \rho }$	0.85
Age-dependent biting parameter	${\displaystyle a_0}$	8 years
Variance of the log heterogeneity in biting rates	${\displaystyle {\sigma }^2}$	1.67
Pre-erythrocytic immunity reducing probability of infection
Duration of refractory period in which immunity is not boosted	${\displaystyle u_B}$	7.19919 days
Duration of pre-erythrocytic immunity	${\displaystyle d_B}$	10 years
Maximum probability of infection due to no immunity	${\displaystyle b_0}$	0.590076
Maximum relative reduction in probability of infection due to immunity	${\displaystyle b_1}$	0.5
Scale parameter	${\displaystyle I_{B0}}$	43.8787
Shape parameter	${\displaystyle K_B}$	2.15506
Immunity reducing probability of clinical disease
Duration of refractory period in which immunity is not boosted	${\displaystyle u_C}$	6.06349 days
Duration of clinical immunity	${\displaystyle d_{CA}}$	30 years
New-born immunity relative to mother’s clinical immunity	${\displaystyle P_{CM}}$	0.774368
Duration of maternal immunity	${\displaystyle d_{CM}}$	67.6952 days
Maximum probability of clinical disease due to no immunity	${\displaystyle {\mathrm{\Phi }}_0}$	0.791666
Maximum relative reduction in probability of clinical disease due to immunity	${\displaystyle {\mathrm{\Phi }}_1}$	0.000737
Scale parameter	${\displaystyle I_{C0}}$	18.02366
Shape parameter	${\displaystyle K_C}$	2.36949
Immunity reducing probability of detection
Duration of refractory period in which immunity is not boosted	${\displaystyle u_D}$	9.44512 days
Duration of detection immunity	${\displaystyle d_{ID}}$	10 years
Minimum probability of detection due to maximum immunity	${\displaystyle d_1}$	0.160527
Scale parameter	${\displaystyle I_{D0}}$	1.577533
Shape parameter	${\displaystyle K_D}$	0.476614
Scale parameter relating age to immunity	${\displaystyle a_D}$	21.9 years
Time-scale at which immunity changes with age	${\displaystyle f_{D0}}$	0.007055
Shape parameter relating age to immunity	${\displaystyle {\gamma }_D}$	4.8183