Appendix 1—table 2. P. vivax human model parameter values.

Full details can be found in the original publication (White et al., 2018) including references for parameters and intervals for the prior and posterior distributions.

Parameter	Symbol	Estimate
Human infection duration (days)
Latent period	$d_E$	10
Light microscopy-detectable asymptomatic infection	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_{LM}$}\right.$	10
Clinical disease (untreated)	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_D$}\right.$	5
Treatment of clinical disease	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_T$}\right.$	1
Prophylaxis	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_P$}\right.$	28
Age, heterogeneity, and probability of infection
Age-dependent biting parameter	$\rho$	0.85
Age-dependent biting parameter	$a_0$	8 years
Variance of the log heterogeneity in biting rates	${\sigma }^2$	1.29
Probability of blood-stage infection upon infectious mosquito bite	$b$	0.5
Hypnozoite parameters
Relapse rate	$f$	0.024 per day
Clearance rate	${\gamma }_L$	0.0026 per day
Maternal immunity
New-born immunity relative to mother’s clinical immunity	$P_{mat}$	0.421
Duration of maternal immunity	$d_{mat}$	35.148 days
Anti-parasite immunity reducing probability of light microscopy-detectable infection and duration of PCR-detectable infection
Duration of refractory period in which immunity is not boosted	$u_{par}$	19.77 days
Duration of anti-parasite immunity	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_{par}$}\right.$	10 years
Maximum probability of detectability by light microscopy due to no immunity	${\Phi }_{LM,max}$	0.8918
Minimum probability of detectability by light microscopy due to full immunity	${\Phi }_{LM,min}$	0.0043
Scale parameter for detectability by light microscopy	$A_{LM,50\%}$	27.52
Shape parameter for detectability by light microscopy	$K_{LM}$	2.403
Maximum duration of PCR-detectable infection due to no immunity	$d_{PCR,max}$	70 days
Minimum duration of PCR-detectable infection due to full immunity	$d_{PCR,min}$	10 days
Scale parameter for duration of PCR-detectable infection	$A_{PCR,50\%}$	9.9
Shape parameter for duration of PCR-detectable infection	$K_{PCR}$	4.602
Clinical immunity reducing probability of clinical disease
Duration of refractory period in which immunity is not boosted	$u_C$	7.85 days
Duration of detection immunity	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$r_C$}\right.$	30 years
Maximum probability of clinical disease due to no immunity	${\displaystyle {\mathrm{\Phi }}_{D,max}}$	0.8605
Minimum probability of clinical disease due to full immunity	${\displaystyle {\mathrm{\Phi }}_{D,min}}$	0.018
Scale parameter for clinical disease	$A_{D,50\%}$	11.538
Shape parameter for clinical disease	$K_D$	2.250