Figure 7. Speculative model based on the most important changes in electrophysiological properties found in STX1A-chimeras or STX2-chimeras compared to their WT isoforms.

Energy landscape for priming and fusion of synaptic vesicles that have SNARE complexes formed with STX1A WT (black line), STX1A-2(SNARE or Cter) (red dotted line), STX2 WT (blue line), and STX2-1A(Cter) (light green dotted line). Summarized conclusions of our results based on the speculative model in. Changes in the equilibrium between the unprimed/primed state (reflecting the stability of the primed state) and the rate of fusion (energy landscape for fusion adapted from Sørensen, 2009).