Appendix 2—table 2. Descriptive group statistics Hamburg City Health Study (HCHS).
| Metric* | Individuals with MetS | Matched controls | Puncorr | PFDR | Stat |
|---|---|---|---|---|---|
| Age (years) | 65.77±7.40 (759) | 65.97±7.52 (759) | 0.613 | 0.647 | 0.03 |
| Sex (% female) | 33.47 | 36.50 | 0.236 | 0.281 | 1.4 |
| Education (ISCED) | 2.37±0.58 (759) | 2.42±0.60 (759) | 0.09 | 0.114 | 0.09 |
| Metabolic syndrome criteria | |||||
| Waist circumference (cm) | 103.38±11.23 (754) | 91.45±11.36 (747) | <0.001 | <0.001† | –1.06 |
| RRsystolic (mmHg) | 145.66±18.54 (740) | 140.17±21.10 (746) | <0.001 | <0.001† | –.28 |
| RRdiastolic (mmHg) | 83.75±10.11 (740) | 82.00±10.40 (746) | 0.001 | 0.002 | –.17 |
| Antihypertensive therapy (%) | 52.60% | 26.22% | <0.001 | <0.001† | 108.89 |
| HDL (mg/dL) | 54.60±16.13 (751) | 67.63±17.46 (759) | <0.001 | <0.001† | 0.78 |
| Triglycerides (mg/dL) | 161.53±92.61 (751) | 91.23±30.62 (759) | <0.001 | <0.001† | –1.02 |
| Lipid lowering therapy (%) | 40.85% | 7.64% | <0.001 | <0.001† | 225.29 |
| Blood glucose (mg/dL) | 107.47±28.59 (742) | 90.99±10.87 (753) | <0.001 | <0.001† | –0.76 |
| Antidiabetic therapy (%) | 14.42% | 1.45% | <0.001 | <0.001† | 85.47 |
| Cognitive scores | |||||
| Animal Naming Test | 23.71±6.46 (712) | 24.77±6.75 (711) | 0.005 | 0.009 | 0.16 |
| Clock Drawing Test | 6.36±1.17 (730) | 6.39±1.16 (733) | 0.774 | 0.774 | 0.02 |
| Trail Making Test A (sec) | 41.26±14.28 (685) | 40.42±14.54 (675) | 0.321 | 0.359 | –0.06 |
| Trail Making Test B (sec) | 93.74±37.30 (675) | 89.89±37.69 (671) | 0.086 | 0.114 | –0.10 |
| Multiple-Choice Vocabulary Intelligence Test | 31.18±3.43 (603) | 31.71±3.22 (619) | 0.019 | 0.034 | 0.16 |
| Word List Recall | 7.42±1.89 (691) | 7.64±1.84 (673) | 0.057 | 0.083 | 0.12 |
| Imaging | |||||
| Mean cortical thickness (mm) | 2.327±0.08 (759) | 2.334±0.08 (757) | 0.045 | 0.071 | 0.1 |
Abbreviations: cm = centimeter, dL = deciliter, HDL = high-density lipoprotein, ISCED = International Standard Classification of Education, MetS = metabolic syndrome, mg = milligram, mm = millimeter, mmHg = millimeters of mercury, Puncor = uncorrected p-values, PFDR = false-discovery rate-corrected p-values, RR = Blood pressure, sec = seconds.
*
Presented as mean ± SD (N).
†
Denotes statistical significance at FDR-corrected p<0.001.