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Preservation of brain volume assessed by vMRI. (A) There was no significant difference between active and sham groups in their PET Composite ROI SUVR referenced to cerebellum (p = 0.318). Active arm participants showed a significantly reduced volumetric change in (B) whole brain volume (p = 0.005), (C) occipital lobe volume (p = 0.019), and (D) occipital cortical thickness (p = 0.013) assessed by MRI at baseline and at 3- and 6-months of the therapy. *p < 0.05, **p < 0.005.
