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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: J Mol Biol. 2024 Jan 22;436(7):168453. doi: 10.1016/j.jmb.2024.168453

Table 2.

Phenotypes of KMT2 knockout and enzyme-dead knockin mice.

Subgroup Genotypes Mouse phenotypes
(developmental defects)		 References
Kmt2a & Kmt2b Kmt2a−/− Embryonic lethal during E10.5–14.5
(hematopoiesis and somitogenesis defects)		 76,80
Kmt2a ΔSET/ΔSET Survive to adulthood
(skeletal abnormalities)		 98,99
Kmt2b−/− Embryonic lethal during E9.5–11.5
(increased apoptosis and retarded development)		 87
Kmt2b M2628K/M2628K Embryonic lethal during E8.5–12.5 100
Kmt2c & Kmt2d Kmt2c −/− Perinatal lethal
(lung maturation defects)		 26,52
Kmt2c Y4792A/Y4792A Survive to adulthood
(no obvious defects)		 21
Kmt2d −/− Embryonic lethal around E9.5
(visceral endoderm migration defects)		 26,52
Kmt2d Y5477A/Y5477A Embryonic lethal around birth
(lung maturation defects)		 21
Kmt2c Y4792A/Y4792A
Kmt2d Y5477A/Y5477A 		Embryonic lethal around E6.5
(fail to gastrulation)		 21
Kmt2f & Kmt2g Kmt2f −/− Embryonic lethal around E7.5
(epiblast proliferation defects)		 9
Kmt2f ΔSET/ΔSET Embryonic lethal during E10.5–12.5 123
Kmt2g −/− Embryonic lethal during E10.5–11.5 9