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. 2024 Feb 16;30(3):785–796. doi: 10.1038/s41591-024-02803-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — Panels A-E are schematic illustrations (that is, cartoons) showing the breakdown of the different types of taxon dynamics we observe in the overall comparison between patients with PFS ≥ 12 months and patients with PFS < 12 months. Yellow and purple slopes correspond to patients with PFS ≥ 12 and PFS < 12 months, respectively. Panel (A) shows dynamics where patients with PFS ≥ 12 and PFS < 12 months are differentially abundant only after T0 (that is, dynamics 1a and 2a). Dynamics 3a is a particular case of dynamics 1a and 2a where the slopes for patients with PFS ≥ 12 and PFS < 12 months intersect. Panel (B) shows dynamics where patients with PFS ≥ 12 and PFS < 12 months are differentially abundant at early but not at late visits (that is, dynamics 1b and 2b). Dynamics 3b is a special case of dynamics 1b and 2b where the patients with PFS ≥ 12 and PFS < 12 months slopes intersect. Panel (C) shows dynamics where the slope of one of the groups is zero (or close to zero) while the other group is either increasing or decreasing, respectively (that is, dynamics 1c and 2c). In panels (D) and (E), included the inset figures, patients with PFS ≥ 12 and PFS < 12 months exhibit parallel lines (that is, no statistical interactions); Panel 1d and 2d shows dynamics where both patients with PFS ≥ 12 and PFS < 12 months are either increasing or decreasing, respectively, while in panels 1f and 2f, the slopes of patients with PFS ≥ 12 and PFS < 12 months are zero (or close to zero). The number in each plot corresponds to the number of microbial SGBs that follow each type of different dynamics.