Fig. 3. Different taxon dynamics in patients with PFS ≥12 and PFS <12 months.

a–d, Four different dynamics exemplified by different microbial SGBs with different dynamics in patients with PFS ≥12 (n₀ = 62, n₁ = 77, n₂ = 38 and n₃ = 30) and PFS <12 (n₀ = 74, n₁ = 69, n₂ = 34 and n₃ = 24) months, where the slopes of patients with PFS ≥12 months (yellow slopes) and patients with PFS <12 months (purple slopes) diverge from similar baseline abundances (a, dynamics 2a, Extended Data Fig. 7a), where the slopes of patients with PFS ≥12 and PFS <12 months are crossing (b, generating opposite abundance patterns when comparing baseline to the last study visit, dynamics 3b, Extended Data Fig. 7b), where the slope of the patients with PFS <12 months is relatively unchanged across the study visits compared to the slope of the patients with patients with PFS ≥12 months (c, dynamics 1c, Extended Data Fig. 7c); where the slope of the patients with PFS ≥12 months is relatively unchanged across the study visits compared to the slope of the patients with PFS <12 months (d, dynamics 2c, Extended Data Fig. 7c). The y axis shows the expected abundance (represented in centered log ratio coordinates) for each study visit (x axis). The corresponding inset figures show the average difference between patients with PFS ≥12 and PFS <12 months at each study visit, including its 90% credible interval. The number (n) represents the number of patient samples at each visit for patients with PFS ≥12 and PFS <12 months.