Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 16;30(3):785–796. doi: 10.1038/s41591-024-02803-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 3 — The extended balance has 12 SGBs in the numerator (A. butyriciproducens [SGB14993 group], I. bartlettii [SGB6140], D. sp AF24 7LB [SGB4571], L. gasseri [SGB7038 group], L. celerecrescens [SGB4868], R. sp NSJ 71 [SGB4290], GGB9640 [SGB15115], E. rectale [SGB4933 group], E. entriosum [SGB5045], E. sp AM28 29 [SGB6796 group], Clostridium sp AF15 49 [SGB5111], and A. bouchesdurhonensis [SGB17152]) and 9 SGBs in the denominator (R. lactatiformans [SGB15271], R. unclassified [SGB15265 group], P. copri clade A [SGB1626], GGB1420 [SGB1957], Gemmiger [SGB15299], B. obeum [SGB4809], Clostridiales unclassified [SGB15145], P. vulgatus [SGB1814], and B. clarus [SGB1832]). Panel (A) balance’s ability to discriminate between patients with PFS ≥ 12 (n = 83; n₀ = 62; n₁ = 77; n₂ = 38; n₃ = 30) and PFS < 12 (n = 92; n₀ = 74; n₁ = 69; n₂ = 34; n₃ = 24) months across study visits. Boxplots represent minima, Q1, Q2, Q3, and maxima. Panel (B) the balance’s predictive ability expressed as the Area Under the Curve (AUC) computed from 100 times repeated five-fold cross-validation (CV). Each line shows, for each study visit, the average across the 100 repeated five-fold CVs with the shaded area representing the 95% confidence interval. Panel (C) Kaplan–Meier curves and multivariable Cox regression analysis of overall survival in 146 patients at baseline (one patient was removed due to missingness in the included predictor variables) according to high (above median) and low (below median) values of the balance after adjusting for age, sex, BMI, previous therapy, PPI and antibiotic use.