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. 2024 Feb 12;30(3):730–739. doi: 10.1038/s41591-023-02791-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Kaplan–Meier estimates of PFS in (a) patients with left-sided primary tumors, (b) patients with right-sided primary tumors and (c) the overall population (all ctDNA-evaluable patients). The forest plots below each Kaplan–Meier plot show the HR ± 95% CI. A Cox proportional hazard model without stratification factors was used to calculate HRs for group comparisons and P values for the interaction between negative hyperselection status and treatment group. Statistical tests were two-sided without adjustment for multiple comparisons. ctDNA, circulating tumor DNA; HR, hazard ratio; mFOLFOX6, modified FOLFOX6.