Table 2.
Characteristics of the patients at baseline.
| LVEF (%) | ≤24% (1472) | 25-33% (1871) | 34-45% (1693) | ≥45% (789) | ||
|---|---|---|---|---|---|---|
| 45-50% (168) | 50-60% (321) | ≥60% (299) | ||||
| Placebo | 751 | 921 | 848 | 59 | 102 | 101 |
| Vericiguat | 721 | 950 | 845 | 110 | 219 | 197 |
| Age (years) | 67.3 (12.2) | 72.7 ( 9.4) | ||||
| Sex: No. (%) | ||||||
| Female | 284 (19.3) | 444 (23.7) | 477 (28.2) | 385 (48.8) | ||
| Male | 1188 (80.7) | 1427 (76.3) | 1216 (71.8) | 404 (51.2) | ||
| Race, No. (%) | ||||||
| White | 859 (58.4) | 1,201 (64.2) | 1,169 (69.0) | 674 (85.4) | ||
| Black | 125 (8.5) | 77 (4.1) | 46 (2.7) | 21 (2.7) | ||
| Asian | 306 (20.8) | 429 (22.9) | 395 (23.3) | 75 (9.5) | ||
| other | 182 (12.4) | 163 (8.7) | 83 (4.9) | 19 (2.4) | ||
| Region, No. (%) | ||||||
| Americas | 431 (29.3) | 519 (27.7) | 493 (29.1) | 155 (19.6) | ||
| Europe | 489 (33.2) | 636 (34.0) | 564 (33.3) | 562 (71.2) | ||
| Asia Pacific | 315 (21.4) | 440 (23.5) | 426 (25.2) | 72 (9.1) | ||
| Latin and South | 237 (16.1) | 276 (14.8) | 210 (12.4) | 0 | ||
| Body mass index, mean (SD) | 26.7 (4.8) | 27.2 (5.3) | 27.5 (5.6) | 30.7 (6.1) | ||
| Blood pressure, mean (SD), mm Hg | ||||||
| Systolic BP, mm Hg | 115.1 (14.1) | 118.7 (14.8) | 124.4 (17.1) | 129.4 (12.6) | ||
| Diastolic BP, mm Hg | 72.4 (11.1) | 72.4 (11.1) | 72.6 (11.1) | 72.9 (10.5) | ||
| Smoking history, No. (%) | 926 (62.9) | 1,084 (57.9) | 955 (56.4) | 342 (43.3) | ||
| Clinical history No. (%) | ||||||
| Hypertension | 1,076 (73.1) | 1,476 (78.9) | 1,432 (84.6) | 729 (92.4) | ||
| Atrial fibrillation | 590 (40.1) | 823 (44.0) | 849 (50.1) | 485 (61.5) | ||
| Coronary artery disease | 990 (67.2) | 1476 (78.9) | 1322 (78) | 362 (45.9) | ||
| Diabetes | 665 (45.2) | 878 (46.9) | 818 (48.3) | 358 (45.4) | ||
| Anemia | 256 (17.4) | 410 (21.9) | 401 (23.7) | 169 (21.4) | ||
| Chronic obstructive pulmonary disease | 226 (15.4) | 322 (17.2) | 316 (18.7) | 154 (19.5) | ||
| Heart rate, mean (SD), /min | 73.7 (13.4) | 72.4 (12.6) | 71.1 (12.6) | 70.4 (10.7) | ||
| eGFR, mean (SD), mL/min/1.73 m2 | 62.3 (27.4) | 58.3 (27.2) | 56.7 (26.2) | 59.5 (20.7) | ||
eGFR, estimated glomerular filtration rate; SD, standard deviation.