Table 2.
Association between patient factors and different trajectories compared to persistent adherence
| Delayed dispensing | Early discontinuation | Late discontinuation | ||||
|---|---|---|---|---|---|---|
| RR [95% CI]a | p-value | RR [95% CI]a | p-value | RR [95% CI]a | p-value | |
| Age, n (%) | ||||||
| 50–64 | 1 | 1 | 1 | |||
| 65–74 | 0.71 [0.42–1.21] | 0.210 | 0.69 [0.32–1.48] | 0.342 | 0.62 [0.28–1.37] | 0.240 |
| 75–84 | 0.67 [0.41–1.11] | 0.119 | 0.81 [0.40–1.63] | 0.555 | 0.70 [0.34–1.45] | 0.340 |
| ≥ 85 | 0.38 [0.22–0.64] | < 0.001 | 0.66 [0.32–1.36] | 0.266 | 0.55 [0.26–1.16] | 0.117 |
| Sex, n (%) | ||||||
| Females | 1 | 1 | 1 | |||
| Males | 0.79 [0.57–1.11] | 0.172 | 1.17 [0.78–1.76] | 0.435 | 1.15 [0.76–1.74] | 0.510 |
| Discharge destination, n (%) | ||||||
| Home-dwelling and otherb | 1 | 1 | 1 | |||
| RACF | 0.68 [0.47–0.93] | 0.119 | 1.42 [0.90–2.24] | 0.136 | 0.84 [0.50–1.42] | 0.511 |
| HFRS, n (%) | ||||||
| < 5 | 1 | 1 | 1 | |||
| 5–15 | 0.66 [0.47–0.93] | 0.019 | 0.97 [0.59–1.60] | 0.902 | 0.89 [0.54–1.47] | 0.645 |
| > 15 | 0.64 [0.37–1.13] | 0.124 | 0.93 [0.46–1.87] | 0.831 | 0.94 [0.47–1.89] | 0.864 |
| Comorbidities | ||||||
| Anxiety | 1.30 [0.75–2.25] | 0.351 | 1.92 [1.08–3.43] | 0.027 | 0.88 [0.43–1.79] | 0.725 |
| Dementia | 0.90 [0.49–1.67] | 0.747 | 0.72 [0.35–1.50] | 0.382 | 1.92 [1.09–3.38] | 0.023 |
| Depression | 0.82 [0.43–1.56] | 0.539 | 0.78 [0.38–1.63] | 0.513 | 1.36 [0.71–2.61] | 0.355 |
| Gastroesophageal reflux | 1.23 [0.75–2.03] | 0.410 | 0.75 [0.35–1.60] | 0.459 | 1.38 [0.75–2.54] | 0.295 |
| Previous falls | 1.00 [0.71–1.41] | 0.988 | 1.43 [0.97–2.11] | 0.073 | 1.06 [0.70–1.59] | 0.786 |
| Previous osteoporosis diagnosis | 1.22 [0.80–1.85] | 0.354 | 1.10 [0.66–1.83] | 0.719 | 1.38 [0.85–2.24] | 0.189 |
| Pre-admission medications | ||||||
| Oral bisphosphonates | 0.28 [0.21–0.39] | < 0.001 | 0.70 [0.49–1.00] | 0.048 | 0.82 [0.57–1.18] | 0.284 |
| Polypharmacy | 0.83 [0.62–1.09] | 0.183 | 0.74 [0.51–1.06] | 0.096 | 1.21 [0.82–1.77] | 0.332 |
RR, relative risk; CI, confidence interval; HFRS, Hospital Frailty Risk Score; RACF, residential aged care facilities. aAdjusted for age, sex, discharge to RACF, HFRS, comorbidities, previous falls, previous osteoporosis diagnosis, pre-admission bisphosphonate use, and pre-admission polypharmacy. bIncluding discharge to private residences, transition care program, mental health accommodation, and transfers from other health care organizations