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. 2024 Mar 8;15:1304853. doi: 10.3389/fgene.2024.1304853

TABLE 1.

Wound healing fibroblast populations, ATAC, and scRNA seq data of genes associated with mechano-fibrotic, activated-responder, and remodeling-proliferator fibroblasts in normal wound healing.

Functional classification Single-cell ATAC-seq markers Single-cell RNA-Seq markers References
Mechano-Fibrotic Col1a1, Acta2, Pdgfra, Ptk2 Pdgfr-a, Ptk2, Tgfb2, Chd2, Coll1a1, Coll1a2, Mest, Plac8, Col3a1, Col5a1 Timp1, Timp2, Mmp3 Foster et al. (2021), Phan et al. (2021), Phan et al. (2020)
Activated-Responder Thbs1, Thbs2 Fn1, Thbs1 Foster et al. (2021)
Remodeling-Proliferator Jak1, Jak2, Jak3, Ptk2b Cxcl2, Spp1, Crabp1 Foster et al., 2021, Phan et al. (2021)