TABLE 2.
Functional classification | Single-cell ATAC-seq markers | Single-cell RNA-Seq markers | References |
---|---|---|---|
MyCAF/MR | Fos, Fosb, Junb, Jund, Runx1/2, Gas6, Yap, Acta2 | Mgp, Gas6, Postn, Fosb, Ptk2, Lrrc15, Spp1, Thbs2, Fsp1, Col6a1, Tgbf2, Cdh11, Acta2, Pdgfrb, Dcn, Lum,Vcan, Col14a1, Fbln1, Fbln2, Smoc, Lox, Loxl1,Cxcl14 | Foster et al. (2022), Bartoschek et al. (2018) |
iCAF | none reported | Il1r1, Myd88, Il6st, Cxcl1 CXCL2, FGF7, FGF10 BMP4/7, HGF, IGF1 | Foster et al. (2022), Wu et al. (2020) |
ImCAF | none reported | Ifngr1, B2m, Cd74, H2-D1, H2-K1, Cxcl12 | Foster et al. (2022) |
CAFs in Treatment Resistance | None reported | PDPN, CD63, CD146 | Du et al. (2023), Gao et al. (2020), Brechbuhl et al. (2017) |