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. 2024 Mar 8;15:1304853. doi: 10.3389/fgene.2024.1304853

TABLE 2.

Breast cancer CAF populations, ATAC, and scRNA seq data of genes associated with CAFs in breast cancer along with genes associated with treatment resistance.

Functional classification Single-cell ATAC-seq markers Single-cell RNA-Seq markers References
MyCAF/MR Fos, Fosb, Junb, Jund, Runx1/2, Gas6, Yap, Acta2 Mgp, Gas6, Postn, Fosb, Ptk2, Lrrc15, Spp1, Thbs2, Fsp1, Col6a1, Tgbf2, Cdh11, Acta2, Pdgfrb, Dcn, Lum,Vcan, Col14a1, Fbln1, Fbln2, Smoc, Lox, Loxl1,Cxcl14 Foster et al. (2022), Bartoschek et al. (2018)
iCAF none reported Il1r1, Myd88, Il6st, Cxcl1 CXCL2, FGF7, FGF10 BMP4/7, HGF, IGF1 Foster et al. (2022), Wu et al. (2020)
ImCAF none reported Ifngr1, B2m, Cd74, H2-D1, H2-K1, Cxcl12 Foster et al. (2022)
CAFs in Treatment Resistance None reported PDPN, CD63, CD146 Du et al. (2023), Gao et al. (2020), Brechbuhl et al. (2017)