TABLE 5.
Functional classification | Single-cell ATAC-seq markers | Single-cell RNA-Seq markers | References |
---|---|---|---|
mCAF | None reported | COL1A1, COL1A2, COL3A1,LUM, POSTN,TNC, COL11A1, PTGDS, Acta2, Rock1, Mcl2, Mick, Col1a1, Col1a2, Fn1, Sparc | Agnes et al. (2023), Davidson et al. (2020) |
iCAF | None reported | Pdpn, Pdgfra, Cd34, Cxcl12, Csf1, Il6, C2, C3, C4b, Postn, Tnc, Ng2, Zeb2, Acta2, Lrrc15, Fbln1, MMP1, MMP3, IL6,CXCL8, IDO1, MMP1 | Davidson et al. (2020), Filipescu et al. (2023), Agnes et al. (2023) |
Short-Term Survival or Treatment Resistance | FAP, FSP, S100A4, TBF-b | CCN2 | Wong et al. (2019), Andersen et al. (2004), Kodama et al. (2021) Hutchenreuther et al. (2018) |