Table 3.
Plasma biomarkers in sepsis phenotypes.
| Sepsis Phenotype | Hypoimmune | Hyperimmune | Hybrid | Control | P value |
|---|---|---|---|---|---|
| Number of Subjects | N=14 | N=23 | N=8 | N=8 | |
| Laboratory Values | |||||
| WBC ×109/L | 13 ± 6 | 16 ± 4 | 16 ± 8 | NA | NS |
| Neutrophils ×109/L | 4 ± 2 | 8 ± 4 | 4 ± 2 | NA | P<0.01 Hyperimmune vs. Hypoimmune and Hybrid |
| Bands (%) | 1 ± 2 | 3 ± 12 | 1 ± 2 | NA | NS |
| Plasma Markers of Endothelial Damage (Mean ± SEM) | |||||
| vWF (pg/ml) | 10753 ± 1340 | 8276 ± 1363 | 6699 ± 752 | 3221 ± 539 | P<0.01 vs. control |
| ICAM-1 (ng/ml) | 145 ± 30 | 178 ± 36 | 192 ± 52 | 42 ± 3 | P<0.001 vs. control |
| Angiopoietin (pg/ml) | 5441 ± 1054 | 6526 ± 1631 | 8563 ± 4755 | 474 ± 37 | P<0.001 vs. control |
| Plasma Cytokine Biomarkers (Mean ± SEM) | |||||
| IL-6 (pg/ml) | 191 ± 96 | 184 ± 46 | 332 ± 107 | 2 ± 0.3 | P<0.02 vs. control |
| IL-8 (pg/ml) | 105 ± 49 | 207 ± 80 | 393 ± 311 | 2 ± 0.4 | P<0.02 vs. control |