Table 2.

Univariable and multivariate Cox regression analysis for prognostic factors of MBC related to overall survival.

Factors	Univariable Cox regression		Multivariate Cox regression
	HR (95%CI)	P-value	HR (95%CI)	P-value
Age(years)	1.11(1.07-1.16)	4.347E-7	1.08(1.03-1.13)	0.001
Tumor size(cm)
< 2.0	1.00(reference)		1.00(reference)
≥ 2.0	4.42(1.68-11.61)	0.003	2.04(0.63-6.59)	0.233
TNM stage
I	1.00(reference)		1.00(reference)
II	2.03(0.62-6.61)	0.240	1.37(0.37-5.05)	0.636
III	3.12(0.96-10.17)	0.059	1.61(0.43-6.00)	0.480
IV	7.41(2.13-25.73)	0.002	2.62(0.54-12.75)	0.233
Ki67
≤15%	1.00(reference)		1.00(reference)
>15%	2.30(1.07-4.92)	0.033	0.87(0.33-2.27)	0.769
ER
Negative	1.00(reference)		1.00(reference)
Positive	0.31(0.11-0.92)	0.035	0.64(0.09-4.54)	0.659
PR
Negative	1.00(reference)		1.00(reference)
Positive	0.31(0.10-0.94)	0.038	0.33(0.05-2.17)	0.247
Type of surgery
No surgery	1.00(reference)		1.00(reference)
Breast conserving surgery1	0.17(0.01-1.96)	0.154	–	–
Radical mastectomy	0.17(0.04-0.75)	0.019	0.26(0.03-1.94)	0.187
Distant metastasis
No	1.00(reference)		1.00(reference)
Yes	4.56(2.17-9.58)	6.200E-5	1.15(0.42-3.14)	0.786
LMR
< 3.67	1.00(reference)		1.00(reference)
≥ 3.67	0.38(0.17-0.86)	0.020	1.58(0.45-5.49)	0.474
PLR
< 113.20	1.00(reference)		1.00(reference)
≥ 113.20	2.83(1.29-6.24)	0.010	0.82(0.29-2.36)	0.713
NLR
< 2.13	1.00(reference)		1.00(reference)
≥ 2.13	3.16(1.39-7.19)	0.006	1.46(0.48-4.42)	0.505

HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, Progesterone receptor; LMR, lymphocyte-to-monocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.

¹ In multivariate Cox regression, there was only one patient in this group, so HR (95%CI) and P-value could not be calculated.