Table 3.
Univariable and multivariate Cox regression analysis for prognostic factors of MBC related to disease-free survival1.
| Factors | Univariable Cox regression | Multivariate Cox regression | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age(years) | 1.06(1.02-1.09) | 0.001 | 1.06(1.02-1.10) | 0.007 |
| Tumor size(cm) | ||||
| < 2.0 | 1.00(reference) | 1.00(reference) | ||
| ≥ 2.0 | 3.19(1.57-6.47) | 0.001 | 2.55(1.05-6.17) | 0.038 |
| Differentiation | ||||
| Well | 1.00(reference) | 1.00(reference) | ||
| Moderate | 1.42(0.43-4.73) | 0.566 | 1.16(0.33-4.05) | 0.822 |
| Poor/ undifferentiated |
3.98(1.37-11.55) | 0.011 | 3.23(1.03-10.12) | 0.044 |
| TNM stage | ||||
| I | 1.00(reference) | 1.00(reference) | ||
| II | 1.56(0.69-3.53) | 0.289 | 1.84(0.65-5.20) | 0.248 |
| III | 1.72(0.61-4.84) | 0.304 | 0.87(0.25-2.97) | 0.818 |
| IV | 29.50(7.62-114.18) | 9.499E-7 | 31.59(6.01-165.93) | 4.500E-5 |
| Ki67 | ||||
| ≤15% | 1.00(reference) | 1.00(reference) | ||
| >15% | 2.74(1.41-5.35) | 0.003 | 1.20(0.53-2.73) | 0.659 |
| LMR | ||||
| < 3.67 | 1.00(reference) | 1.00(reference) | ||
| ≥ 3.67 | 0.50(0.26-0.96) | 0.037 | 0.97(0.44-2.13) | 0.933 |
HR, hazard ratio; CI, confidence interval; PR, progesterone receptor; LMR, lymphocyte-to-monocyte ratio; PLR, platelet-to-lymphocyte ratio.
1Only patients who did not develop distant metastases during the follow-up period were retained in this analysis.