Table 1.
Top 30 differentially upregulated and downregulated genes between N-dECM_DPSCs and N-dECM_GSCs, and between OM-dECM_DPSCs and OM-dECM_GSCs.
| Ensembl gene ID | Gene symbol | Gene name | LogFc | P value |
|---|---|---|---|---|
| Upregulated genes compared between N-dECM_DPSCs and N-dECM_GSCs | ||||
| ENSG00000211455 | STK38L | Serine/threonine kinase 38 like | 0.9864 | 2.55E − 18 |
| ENSG00000138135 | CH25H | Cholesterol 25-hydroxylase | 0.9938 | 6.61E − 09 |
| ENSG00000175745 | NR2F1 | Nuclear receptor subfamily 2 group F member 1 | 0.9974 | 1.59E − 12 |
| ENSG00000144476 | ACKR3 | Atypical chemokine receptor 3 | 0.9985 | 5.30E − 09 |
| ENSG00000149968 | MMP3 | Matrix metallopeptidase 3 | 1.0066 | 2.10E − 32 |
| ENSG00000164251 | F2RL1 | Coagulation factor II (thrombin) receptor-like 1 | 1.0075 | 1.23E − 11 |
| ENSG00000157680 | DGKI | Diacylglycerol kinase iota | 1.0075 | 4.16E − 16 |
| ENSG00000133110 | POSTN | Periostin osteoblast specific factor | 1.0143 | 3.42E − 11 |
| ENSG00000271216 | LINC01050 | Long intergenic non-protein coding RNA 1050 | 1.0145 | 7.01E − 14 |
| ENSG00000135362 | PRR5L | Proline rich 5 like | 1.0166 | 1.38E − 21 |
| ENSG00000109272 | PF4V1 | Platelet factor 4 variant 1 | 1.0204 | 8.28E − 12 |
| ENSG00000103546 | SLC6A2 | Solute carrier family 6 (neurotransmitter transporter) member 2 | 1.0245 | 2.16E − 09 |
| ENSG00000148848 | ADAM12 | ADAM metallopeptidase domain 12 | 1.0258 | 2.24E − 39 |
| ENSG00000198535 | C2CD4A | C2 calcium-dependent domain containing 4A | 1.0545 | 4.67E − 10 |
| ENSG00000107317 | PTGDS | Prostaglandin D2 synthase | 1.0563 | 8.19E − 28 |
| ENSG00000125845 | BMP2 | Bone morphogenetic protein 2 | 1.1378 | 9.69E − 17 |
| ENSG00000124875 | CXCL6 | Chemokine (C-X-C motif) ligand 6 | 1.1728 | 1.15E − 43 |
| ENSG00000174792 | C4orf26 | Chromosome 4 open reading frame 26 | 1.1783 | 5.72E − 12 |
| ENSG00000102468 | HTR2A | 5-Hydroxytryptamine (serotonin) receptor 2A G protein-coupled | 1.1802 | 1.61E − 16 |
| ENSG00000113361 | CDH6 | Cadherin 6 type 2 K-cadherin | 1.2225 | 1.48E − 23 |
| ENSG00000188064 | WNT7B | Wingless-type MMTV integration site family member 7B | 1.2393 | 1.20E − 13 |
| ENSG00000198729 | PPP1R14C | Protein phosphatase 1 regulatory (inhibitor) subunit 14C | 1.275 | 5.23E − 14 |
| ENSG00000124225 | PMEPA1 | Prostate transmembrane protein androgen induced 1 | 1.2905 | 5.52E − 82 |
| ENSG00000143341 | HMCN1 | Hemicentin 1 | 1.3492 | 2.18E − 50 |
| ENSG00000174343 | CHRNA9 | Cholinergic receptor nicotinicalpha 9 | 1.3689 | 8.15E − 19 |
| ENSG00000095752 | IL11 | Interleukin 11 | 1.435 | 1.10E − 19 |
| ENSG00000171951 | SCG2 | Secretogranin II | 1.5984 | 1.30E − 53 |
| ENSG00000166670 | MMP10 | Matrix metallopeptidase 10 | 1.6177 | 2.91E − 99 |
| ENSG00000145794 | MEGF10 | Multiple EGF-like-domains 10 | 1.6768 | 6.98E − 45 |
| ENSG00000162490 | DRAXIN | Dorsal inhibitory axon guidance protein | 1.7635 | 1.85E − 30 |
| Downregulated genes compared between N-dECM_DPSCs and N-dECM_GSCs | ||||
| ENSG00000140465 | CYP1A1 | Cytochrome P450 family 1 subfamily A polypeptide 1 | − 1.9653 | 8.05E − 37 |
| ENSG00000168477 | TNXB | Tenascin XB | − 1.3258 | 2.39E − 33 |
| ENSG00000171345 | KRT19 | Keratin 19 | − 1.2923 | 1.31E − 16 |
| ENSG00000246430 | LINC00968 | Long intergenic non-protein coding RNA 968 | − 1.1767 | 3.28E − 25 |
| ENSG00000215853 | RPTN | Repetin | − 1.1412 | 5.01E − 12 |
| ENSG00000143631 | FLG | Filaggrin | − 1.1264 | 3.02E − 15 |
| ENSG00000107984 | DKK1 | Dickkopf WNT signaling pathway inhibitor 1 | − 1.0694 | 1.01E − 13 |
| ENSG00000141574 | SECTM1 | Secreted and transmembrane 1 | − 1.0547 | 1.82E − 22 |
| ENSG00000167641 | PPP1R14A | Protein phosphatase 1 regulatory (inhibitor) subunit 14A | − 1.0504 | 1.65E − 13 |
| ENSG00000154027 | AK5 | Adenylate kinase 5 | − 1.0411 | 4.00E − 28 |
| ENSG00000215182 | MUC5AC | Mucin 5AC oligomeric mucus/gel-forming | − 1.0376 | 5.50E − 10 |
| ENSG00000178882 | FAM101A | Family with sequence similarity 101 member A | − 1.0179 | 1.38E − 09 |
| ENSG00000082482 | KCNK2 | Potassium channel subfamily K member 2 | − 0.9892 | 1.46E − 22 |
| ENSG00000188581 | KRTAP1-1 | Keratin associated protein 1–1 | − 0.9712 | 1.44E − 08 |
| ENSG00000145681 | HAPLN1 | Hyaluronan and proteoglycan link protein 1 | − 0.9422 | 1.15E − 15 |
| ENSG00000107738 | C10orf54 | Chromosome 10 open reading frame 54 | − 0.9407 | 5.27E − 15 |
| ENSG00000166949 | SMAD3 | SMAD family member 3 | − 0.9237 | 5.21E − 45 |
| ENSG00000183287 | CCBE1 | Collagen and calcium binding EGF domains 1 | − 0.9185 | 2.57E − 14 |
| ENSG00000104725 | NEFL | Neurofilament light polypeptide | − 0.9067 | 7.57E − 16 |
| ENSG00000163661 | PTX3 | Pentraxin 3 | − 0.9024 | 1.91E − 19 |
| ENSG00000173641 | HSPB7 | Heat shock 27 kDa protein family member 7 | − 0.8888 | 3.16E − 16 |
| ENSG00000179314 | WSCD1 | WSC domain containing 1 | − 0.8863 | 5.00E − 15 |
| ENSG00000131737 | KRT34 | Keratin 34 | − 0.8826 | 1.97E − 07 |
| ENSG00000130600 | H19 | H19 imprinted maternally expressed transcript (non-protein coding) | − 0.8592 | 1.81E − 07 |
| ENSG00000198910 | L1CAM | L1 cell adhesion molecule | − 0.8575 | 6.50E − 11 |
| ENSG00000123405 | NFE2 | Nuclear factor erythroid 2 | − 0.8327 | 7.18E − 07 |
| ENSG00000243137 | PSG4 | Pregnancy specific beta-1-glycoprotein 4 | − 0.8144 | 5.87E − 12 |
| ENSG00000185112 | FAM43A | Family with sequence similarity 43 member A | − 0.8117 | 2.74E − 07 |
| ENSG00000125965 | GDF5 | Growth differentiation factor 5 | − 0.8107 | 3.47E − 07 |
| ENSG00000127951 | FGL2 | Fibrinogen-like 2 | − 0.8076 | 1.71E − 06 |
| Upregulated genes compared between OM-dECM_DPSCs and OM-dECM_GSCs | ||||
| ENSG00000223414 | LINC00473 | Long intergenic non-protein coding RNA 473 | 1.3696 | 4.08E − 09 |
| ENSG00000129422 | MTUS1 | Microtubule associated tumor suppressor 1 | 1.3976 | 3.69E − 08 |
| ENSG00000125845 | BMP2 | Bone morphogenetic protein 2 | 1.4088 | 6.46E − 07 |
| ENSG00000112320 | SOBP | Sine oculis binding protein homolog | 1.4169 | 8.41E − 08 |
| ENSG00000169116 | PARM1 | Prostate androgen-regulated mucin-like protein 1 | 1.4173 | 5.19E − 11 |
| ENSG00000145335 | SNCA | Synuclein alpha (non A4 component of amyloid precursor) | 1.4200 | 7.84E − 07 |
| ENSG00000188064 | WNT7B | Wingless-type MMTV integration site family member 7B | 1.4207 | 2.35E − 06 |
| ENSG00000124225 | PMEPA1 | Prostate transmembrane protein androgen induced 1 | 1.4216 | 2.32E − 14 |
| ENSG00000196843 | ARID5A | AT rich interactive domain 5A (MRF1-like) | 1.4296 | 3.64E − 14 |
| ENSG00000125430 | HS3ST3B1 | Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 | 1.4397 | 1.73E − 07 |
| ENSG00000133110 | POSTN | Periostin osteoblast specific factor | 1.4460 | 2.76E − 09 |
| ENSG00000149968 | MMP3 | Matrix metallopeptidase 3 | 1.4676 | 1.10E − 22 |
| ENSG00000271216 | LINC01050 | Long intergenic non-protein coding RNA 1050 | 1.4700 | 6.97E − 11 |
| ENSG00000175745 | NR2F1 | Nuclear receptor subfamily 2 group F member 1 | 1.4759 | 3.72E − 12 |
| ENSG00000138135 | CH25H | Cholesterol 25-hydroxylase | 1.5022 | 3.90E − 08 |
| ENSG00000107859 | PITX3 | Paired-like homeodomain 3 | 1.5133 | 4.26E − 07 |
| ENSG00000145423 | SFRP2 | Secreted frizzled-related protein 2 | 1.5327 | 3.04E − 07 |
| ENSG00000140807 | NKD1 | Naked cuticle homolog 1 (Drosophila) | 1.5332 | 1.64E − 07 |
| ENSG00000109819 | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1 alpha | 1.5474 | 8.42E − 22 |
| ENSG00000180616 | SSTR2 | Somatostatin receptor 2 | 1.5520 | 8.61E − 11 |
| ENSG00000167874 | TMEM88 | Transmembrane protein 88 | 1.2393 | 1.24E − 07 |
| ENSG00000145794 | MEGF10 | Multiple EGF-like-domains 10 | 1.2750 | 2.58E − 15 |
| ENSG00000184995 | IFNE | INTERFERON epsilon | 1.2905 | 2.42E − 11 |
| ENSG00000054598 | FOXC1 | Forkhead box C1 | 1.3492 | 3.74E − 22 |
| ENSG00000150907 | FOXO1 | Forkhead box O1 | 1.3689 | 1.63E − 12 |
| ENSG00000120659 | TNFSF11 | Tumor necrosis factor (ligand) superfamily member 11 | 1.4350 | 1.72E − 10 |
| ENSG00000138795 | LEF1 | Lymphoid enhancer-binding factor 1 | 1.5984 | 5.15E − 13 |
| ENSG00000095752 | IL11 | Interleukin 11 | 1.6177 | 1.54E − 22 |
| ENSG00000198535 | C2CD4A | C2 calcium-dependent domain containing 4A | 1.6768 | 4.91E − 30 |
| ENSG00000205502 | C2CD4B | C2 calcium-dependent domain containing 4B | 1.7635 | 8.49E − 39 |
| Downregulated genes compared between OM-dECM_DPSCs and OM-dECM_GSCs | ||||
| ENSG00000188581 | KRTAP1-1 | Keratin associated protein 1–1 | − 1.880 | 7.37E − 11 |
| ENSG00000140465 | CYP1A1 | Cytochrome P450 family 1 subfamily Apolypeptide 1 | − 1.823 | 2.15E − 14 |
| ENSG00000100739 | BDKRB1 | Bradykinin receptor B1 | − 1.708 | 2.09E − 17 |
| ENSG00000143631 | FLG | Filaggrin | − 1.652 | 8.68E − 18 |
| ENSG00000246430 | LINC00968 | Long intergenic non-protein coding RNA 968 | − 1.605 | 2.82E − 08 |
| ENSG00000205426 | KRT81 | Keratin 81 | − 1.482 | 1.86E − 09 |
| ENSG00000215853 | RPTN | Repetin | − 1.458 | 5.05E − 09 |
| ENSG00000185112 | FAM43A | Family with sequence similarity 43 member A | − 1.448 | 5.95E − 19 |
| ENSG00000130600 | H19 | H19 imprinted maternally expressed transcript (non-protein coding) | − 1.434 | 1.28E − 06 |
| ENSG00000221852 | KRTAP1-5 | Keratin associated protein 1–5 | − 1.432 | 1.72E − 06 |
| ENSG00000127951 | FGL2 | Fibrinogen-like 2 | − 1.418 | 2.16E − 06 |
| ENSG00000173267 | SNCG | Synuclein gamma (breast cancer-specific protein 1) | − 1.416 | 2.52E − 08 |
| ENSG00000131737 | KRT34 | Keratin 34 | − 1.410 | 2.88E − 07 |
| ENSG00000183287 | CCBE1 | Collagen and calcium binding EGF domains 1 | − 1.376 | 2.45E − 12 |
| ENSG00000212724 | KRTAP2-3 | Keratin associated protein 2–3 | − 1.349 | 3.75E − 06 |
| ENSG00000014257 | ACPP | Acid phosphatase prostate | − 1.349 | 1.56E − 07 |
| ENSG00000115523 | GNLY | Granulysin | − 1.342 | 3.14E − 07 |
| ENSG00000146250 | PRSS35 | Protease serine 35 | − 1.291 | 2.01E − 10 |
| ENSG00000106003 | LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | − 1.274 | 4.71E − 10 |
| ENSG00000171346 | KRT15 | Keratin 15 | − 1.269 | 1.34E − 06 |
| ENSG00000166949 | SMAD3 | SMAD family member 3 | − 1.249 | 6.82E − 16 |
| ENSG00000184599 | FAM19A3 | Family with sequence similarity 19 (chemokine (C–C motif)-like) member A3 | − 1.248 | 2.62E − 05 |
| ENSG00000162591 | MEGF6 | Multiple EGF-like-domains 6 | − 1.244 | 2.68E − 16 |
| ENSG00000253230 | LINC00599 | Long intergenic non-protein coding RNA 599 | − 1.233 | 3.85E − 05 |
| ENSG00000225968 | ELFN1 | Extracellular leucine-rich repeat and fibronectin type III domain containing 1 | − 1.224 | 6.20E − 12 |
| ENSG00000074527 | NTN4 | Netrin 4 | − 1.223 | 4.45E − 12 |
| ENSG00000135480 | KRT7 | Keratin 7 | − 1.218 | 2.23E − 05 |
| ENSG00000169583 | CLIC3 | Chloride intracellular channel 3 | − 1.208 | 3.41E − 05 |
| ENSG00000105974 | CAV1 | Caveolin 1 caveolae protein 22 kDa | − 1.207 | 1.29E − 05 |
| ENSG00000183671 | GPR1 | G protein-coupled receptor 1 | − 1.203 | 1.97E − 06 |