TABLE 2.
Criteria for the definition of responder and non-responder to treatment.
| Criteria for response |
|---|
| 1. Any positive variation of CGI-S of >= 2 points |
| 2. Any CGI-S = 1 |
| 3. CGI-I <= 2 |
| 4. Duration of treatment >= 90 days |
| 5. No other antipsychotics or mood stabilizers added |
| 6. No dose increase after 90 days of treatment |
| Definition of responder (any of the 4 choices below) |
|---|
| 1. Criteria 1 satisfied |
| 2. Criteria 2 satisfied if not in contrast with criteria 1 |
| 3. Criteria 3 satisfied if not in contrast with criteria 1 and 2 |
| 4. Criteria 4 + 5 + 6 satisfied if not in contrast with criteria 1, 2 and 3 |
| Criteria for non-response |
|---|
| 1. Maximum positive variation of CGI-S< 2 points |
| 2. CGI-I >2 at any observations |
| 3. Beginning of a new follow up with a different antipsychotic, 75–105 days after withdrawal of the AP under study. The switch is not due to side effects of the discontinued medication |
| 4. An antipsychotics or mood stabilizers added after beginning of the antipsychotic under study |
| Definition of non-responder (any of the 3 choices below) |
|---|
| 1. Criteria 1 satisfied |
| 2. Criteria 2 satisfied if not in contrast with criteria 1 |
| 3. Criteria 3 or 4 satisfied if not in contrast with criteria 1 and 2 |
Responder status was considered as unknown in cases not described above and such patients were not included in the analysis. For each participant, a period of 1 year after the inclusion in PsyMetab cohort was considered. Variation of CGI considered were at least 30 days apart. CGI-S = clinical global impression, severity of symptoms scale; CGI-I = clinical global impression, improvement scale.