TABLE 6.
PRSresponse values in responders and non-responders and logistic multivariate regression analysis between PRSresponse and response to treatment.
| N | PRSresponse mean ± SD (range) | Or (95%C.I.) | P | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Cutoff | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Responders | Non-responders | |||||||||
| All patients | 460 | 6.15 ± 1.96 (1.99–11.91) | 5.69 ± 1.92 (0.098–11.96) | 1.14 (1.03–1.26) | 0.01 | 63 | 58 | 64 | 57 | 5.66 |
| SCZ, SA, BD | 235 | 6.19 ± 1.79 (1.99–10.86) | 5.60 ± 1.94 (0.098–11.96) | 1.18 (1.02–1.37) | 0.02 | 60 | 56 | 62 | 53 | 5.58 |
| SCZ, SA | 176 | 6.26 ± 1.77 (2.97–10.86) | 5.52 ± 2.06 (0.098–11.96) | 1.24 (1.04–1.47) | 0.01 | 56 | 55 | 59 | 52 | 5.02 |
| SCZ | 149 | 6.13 ± 1.76 (2.97–10.86) | 5.34 ± 1.90 (1.96–11.96) | 1.27 (1.04–1.55) | 0.01 | 62 | 61 | 66 | 57 | 5.02 |
| SA | 27 | 7.13 ± 1.67 (5.01–9.89) | 6.32 ± 2.60 (0.098–9.03) | 1.78 (0.91–3.52) | 0.09 | 83 | 87 | 83 | 87 | 5.00 |
| BD | 59 | 6.02 ± 1.84 (2.00–10.75) | 5.91 ± 1.47 (3.94–8.97) | 1.00 (0.71–1.41) | 0.98 | 86 | 29 | 64 | 58 | 5.33 |
| Others | 96 | 6.00 ± 2.08 (2.00–10.95) | 5.96 ± 1.86 (1.97–9.93) | 0.98 (0.76–1.26) | 0.87 | 66 | 77 | 74 | 70 | 6.97 |
Results corrected for age PC1, PC2, PC3, PC4, PC5. SCZ, schizophrenia; SA, schizoaffective disorder; BD, bipolar disorder; Others include neurocognitive disorder, substance abuse disorder, depression, miscellaneous; N, number of patients; OR, odds ratio; 95%CI: 95% confidence interval; P, p-value, statistically significant results in bold; PC, genetic principal components; PPV, positive predictive value; NPV, negative predictive value; cutoff, empirical optimal cut-off value to separate responders and non-responders, calculated according to the Youden’s method.