TABLE 8.
PRSschizophrenia2 values in responders and non-responders and logistic multivariate regression analysis between PRSschizophrenia and response to treatment.
| N | PRS mean ± SD (range) | OR (95% CI) | P | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Cutoff | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Responders | Non-Responders | |||||||||
| All patients | 460 | −0.37 ± 0.61 (−2.14—1.21) | −0.33 ± 0.55 (−1.65—1.05) | 0.82 (0.59–1.14) | 0.24 | 61 | 55 | 62 | 54 | −3.5 |
| SCZ, SA, BD | 235 | −0.34 ± 0.59 (−2.14/1.08) | −0.31 ± 0.58 (−1.65/1.05) | 1.04 (0.73–1.48) | 0.82 | 60 | 57 | 63 | 54 | −2.65 |
| SCZ, SA | 176 | −0.36 ± 0.59 (−2.14/1.08) | −0.30 ± 0.61 (−1.65/1.04) | 0.88 (0.53–1.46) | 0.62 | 66 | 62 | 67 | 61 | −0.90 |
| SCZ | 149 | −0.34 ± 0.61 (−2.14/1.08) | −0.32 ± 0.57 (−1.54/1.05) | 0.98 (0.55–1.70) | 0.93 | 59 | 57 | 62 | 53 | −3.01 |
| SA | 27 | −0.41 ± 0.45 (−1.13/0.24) | −0.24 ± 0.80 (−1.65/0.83) | 0.80 (0.16–0.94) | 0.78 | 67 | 93 | 89 | 78 | −1.32 |
| BD | 59 | −0.31 ± 0.59 (−1.64/0.52) | −0.31 ± 0.46 (−1.23/0.56) | 1.11 (0.35–1.00) | 0.86 | 57 | 50 | 62 | 44 | −0.010 |
| Others | 96 | −0.36 ± 0.56 (−2.09/0.89) | −0.33 ± 0.54 (−1.52/0.88) | 0.61 (0.25–1.47) | 0.27 | 68 | 71 | 70 | 70 | −3.47 |
Results corrected for age, PC1, PC2, PC3, PC4, PC5. SCZ schizophrenia; SA, schizoaffective disorder; BD bipolar disorder; others include neurocognitive disorder, substance abuse disorder, depression, miscellaneous; N, number of patients; OR, odds ratio; 95% CI: 95 confidence interval; P, p-value; PC genetic principal components; PPV, positive predictive value; NPV, negative predictive value; cutoff, empirical optimal cut-off value to separate responders and non-responders, calculated according to the Youden’s method.