Table 2.

Time to death using the conventional survival analysis of the ITT population for the RCT and OLE

	Inhaled treprostinil	Placebo
Number of deaths
INCREASE RCT	10	12
INCREASE OLE	29	33
Mean time to death, weeks	58.5	43.5
Median time to death, weeks	65.0	33.1
P value (log-rank test)	0.1209
KM survival estimates
26 weeks (95% CI)	92.7 (87.1 to 95.9)	88.0 (81.4 to 92.4)
52 weeks (95% CI)	89.0 (82.3 to 93.3)	76.5 (67.8 to 83.2)
78 weeks (95% CI)	79.8 (71.1 to 86.1)	67.3 (57.3 to 75.4)
104 weeks (95% CI)	67.5 (57.4 to 75.8)	60.4 (49.8 to 69.5)

ITT, intention to treat; KM, Kaplan-Meier; OLE, open-label extension; RCT, randomised controlled trial.