Table 1.
Rates of safety from the literature for endovascular treatment of unruptured and ruptured aneurysms
| N Aneurysms (subjects) |
Mortality at discharge | Overall complication rate | Rupture/ perforation rate (%) |
Embolism rate (%) | |
| Ruptured intracranial aneurysms | |||||
| Algra et al 2019* 33 | 73 066 (71 819) | 0.3% (0.2–0.4%) | 4.96% (4.00, 6.12%) | 0.9% (212/18 520) 95% CI (0.6% to 1.3%) |
2.82% (437/16 000) 95% CI (2.3% to 3.5%) |
| Advanced endovascular methods†33 | 2248 | 0.4% (0.2–1.1%) | 6.1% (4.3, 8.7%) | ||
| Kawbata et al 201834 | 1406 (1375) | 1.4% (20/1406) | |||
| Coil only | 340 | 1.8% (6/340) | |||
| Stent-assisted coiling | 468 | 0.9% (4/468) | |||
| Balloon-assisted coiling | 598 | 1.7% (10/598) | |||
| From lit review, table 6 in Kawbata34 | 7785 | 0% | 1.4% (108/7785) | ||
| Zheng et al 201635 | 1127 | 1% (11/1127) | |||
| Santillan et al 2013 36 | 217 | 0% | 1.1% (3/217) | ||
| Shigematsu et al 201337 | 4767 | 1.4% (65/4767) | |||
| Oishi et al 201238 | 500 | 0% | 1.4% (7/500) | ||
| Im et al 200939 | 435 | 0% | 0.9% (4/435) | ||
| Pierot et al 200840 | 739 (649) | 0.3% | 2.4% (18/739) | 7.3% (29/398) | |
| (ATENA study) | (700 procs) | 1.4% (1 month) | 15.4% | 2.6% (18/700) | 7.1% (per proc) |
| Pierot et al 200941
(ATENA study, coil alone results) |
325 | 0.9% (3/325) | 10.8% (35/325) | 2.1% (7/325) | 6.2% (20/325) |
| Ruptured intracranial aneurysms | |||||
| Zhang et al 201942 | 1004 | All cause 9.5% (5.8%, 13.2%) procedure related 1.8% (0.9, 2.7%) | 22.7%‡ 95% CI (15.1% to 30.3%) | ||
| Cognard et al 201143
(CLARITY GDC study) |
405 | 1.50% | 3.7% (15/405) | 13.3% (54/405) | |
| Pierot et al 2011 (CLARITY)44 | 608 | 5.1% (31/608) cum. treatment-related morbidity/mortality rate 19.6% (119/608) with. morbidity/mortality rate) |
17.4% (106/608) | 4.6% (28/608) | |
*Rates presented are pooled crude risk from meta-analysis modeling.
†Advanced=stent-assisted coiling, balloon-assisted coiling, flow diverting stents or Woven Endobridge devices.
‡Definition not specified.