Table 2.

Agreement of PD-L1 positivity between biopsies and surgical specimens for each assay and score using Cohen’s kappa statistics

Assay	IC ≥1% (95% CI)	P value	TPS ≥1% (95% CI)	P value	CPS ≥1 (95% CI)	P value	CPS ≥10 (95% CI)	P value
22C3 (n=29)	0.47 (0.182 to 0.758)	0.006	0.592 (0.252 to 0.931)	0.001	0.511 (0.215 to 0.806)	0.003	0.216 (−0.202 to 0.634)	0.241
SP142 (n=33)	0.154 (−0.015 to 0.322)	0.97	n.a.		0.192 (−0.009 to 0.394)	0.061	n.a.
SP263 (n=32)	0.525 (0.219 to 0.832)	0.003	0.525 (0.219 to 0.832)	0.003	0.525 (0.219 to 0.832)	0.003	0.751 (0.524 to 0.978)	0.0001

CPS, Combined Positive Score; IC, immune cell; n.a., not available; TPS, Tumour Proportion Score.