Table 1.

Dose-escalation or de-escalation rule for the Bayesian optimal interval design.

Actions	The number of patients treated at the current dose
	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Escalate if the number of DLTa is ≤	0	0	0	0	1	1	1	1	2	2	2	2	3	3	3
De-escalate if the number of DLT is ≥	1	1	2	2	2	3	3	3	4	4	4	5	5	6	6
Eliminate if the number of DLT is ≥	N/Ab	N/A	3	3	4	4	5	5	5	6	6	7	7	8	8

^aDLT: dose-limiting toxicity.

^bN/A: not applicable.