Table 2.

Study calendar.

		Screening visit, from 7 to 30 days	Enrollment visit, day 0	Treatment days 1-7	Follow-up visit, day 8 (+3-day window)
Required assessments
	Informed consent	✓
	Medical historya		✓
	Height and weight		✓
	Physical examination		✓		✓
	Vital signs		✓		✓
	ECOGb performance status	✓	✓		✓
	EKGc	✓			✓
	Blood chemistriesd	✓			✓
	Hemoglobin, absolute neutrophil count, and platelets	✓			✓
	Urine pregnancy	✓	✓
	Medication assessmente	✓	✓		✓
	Adverse event assessment		✓		✓
Questionnaires
	Physician questionnaire		✓
	Study coordinator questionnaire		✓		✓
	Patient questionnaire (VASf, BPIg, PROMISh, and COMPATi)	✓	✓		✓
	Medication diary	✓	✓		✓

^aMedical history and establishment of suspected or definite chronic pancreatitis diagnosis may occur at any time before trial entry.

^bECOG: Eastern Cooperative Oncology Group.

^cEKG: electrocardiogram.

^dWill include at a minimum: electrolytes, glucose, blood urea nitrogen, creatinine and creatinine clearance, calcium, and hepatic function panel.

^eWill include detailed use of rescue pain medications and opioids use.

^fVAS: Visual Analog Score.

^gBPI: Brief Pain Inventory.

^hPROMIS: Patient-Reported Outcomes Measurement Information System.

ⁱCOMPAT: Comprehensive Pain Assessment Tool for Chronic Pancreatitis.