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. 2024 Feb 15;15(6):1169–1184. doi: 10.1021/acschemneuro.3c00757

Figure 2.

Figure 2

Recovery from inactivation is limited by compound unbinding. Plots of normalized recovery from inactivation in NaV1.6 channels induced by a 10s prepulse to 0 mV in the presence of different concentrations of compounds at −120 mV measured using the protocol shown in inset. (A) XPC-7224, n = 4–12 cells per concentration (B) XPC-5462, n = 3–8 cells per concentration (C) PHY, n = 6–17 cells per concentration (D) CBZ, n = 3–13 cells per concentration. (E) Time constants of the slow component of recovery induced by compound binding against concentration of compound measured at 1.7 s. (F) Plot of the fractional recovery after 1.7 s against compound concentration for XPC-7224 (n = 78 cells), XPC-5462 (n = 63 cells), and PHY (n = 109 cells). Mean data were fit with a double exponential function.