. 2024 Feb 15;15(6):1169–1184. doi: 10.1021/acschemneuro.3c00757

Table 1. Potency of Na_V Channel Subtype Inhibition of Compounds.

	XPC-7724			XPC-5462			phenytoin			carbamazepine
	IC₅₀	95% CI	N (cells)	IC₅₀	95% CI	N (cells)	IC₅₀	95% CI	N (cells)	IC₅₀	95% CI	N (cells)
hNa_V1.1	294	255–354	71	8.75	7.53–10.2	62	13.8	9.59–20.1	26	39.3	33.3–46.7	41
hNa_V1.2	14.3	12.2–16.9	32	0.0109	0.00968–0.0122	49	35.2	2.1–44.3	26	67.4	57.3–79.6	35
hNa_V1.3	167	117–268	45	206	1.85–2.30	63
hNa_V1.4	153	123–197	41	20.8	19.1–22.7	42
hNa_V1.5	138	103–197	15	11.9	10.4–13.5	27	23.8	19.2–29.6	23	41.1	35.3–47.8	39
hNa_V1.6	0.078	0.0718–0.0848	70	0.0103	0.000921–0.0115	50	13	10.1–16.9	29	25.6	21.1–30.8	45
hNa_V1.7	27.7	20.4–40.1	45	0.192	0.175–0.211	54
mNa_V1.6	0.13	0.103–0.164	30	0.0137	0.0112–0.0169	30

Table 1. Potency of NaV Channel Subtype Inhibition of Compounds.