Table 2.

Adjusted^a associations between hypoglycemia and odds of following stable/increasing eBFP trajectory (males) or increasing estimated body fat percentage trajectory (females) comparing those with more vs. less hypoglycemia as defined by median split and clinical cut-points.

Hypoglycemia metric	Males (n = 104)	p value	Females (n = 107)	p value
	Odds of stable/increasing vs. decreasing eBFP trajectory (odds ratio, 95% confidence interval)		Odds of increasing vs. stable/decreasing eBFP trajectory (odds ratio, 95% confidence interval)
% time <70 mg/dL
More vs. lessb	0.40 (0.17, 0.92)	0.03	0.44 (0.19, 1.04)	0.06
≥4% vs. <4%	0.27 (0.10, 0.72)	0.009	0.61 (0.48, 2.46)	0.27
% time 54–69 mg/dL
More vs. less	0.33 (0.14, 0.78)	0.01	0.29 (0.12, 0.69)	0.005
% time <54 mg/dL
More vs. less	0.60 (0.26, 1.36)	0.22	0.53 (0.23, 1.21)	0.13
≥1% vs. <1%	0.40 (0.16, 0.1.0)	0.05	1.10 (0.46, 2.67)	0.83

^aModels adjusted for baseline eBFP, age, clinical site (Ohio, Colorado), and trial group (intervention, control).

^bParticipants categorized into more vs. less group based on whether percent time spent in hypoglycemia was above or below the median of the entire study cohort (n = 211; median <70 mg/dL: 2.0%; median 54–69 mg/dL: 1.5%; median <54 mg/dL: 0.3%.