Table 2:

Mean difference in number of toxicities (grade ≥2 and grade ≥3) among different categories of polypharmacy, PIM, and major PDI

Predictor/ outcome	Mean difference in number of grade ≥ 2 toxicities		Mean difference in number of grade ≥ 3 toxicities
	Unadjusted model	Adjusted model *	Unadjusted model	Adjusted model *
Polypharmacy (≥8 versus <8)	2.10 (8.25)**	1.87 (0.71)**	0.67 (3.30)**	0.59 (0.29)**
Polypharmacy (continuous)***	0.24 (0.09)**	0.21 (0.10)**	0.07 (0.04)**	0.06 (0.04)
PIM (yes versus no)	0.41 (8.31)	--	0.19 (3.31)	--
Major PDI (yes versus no)	0.07 (8.31)	--	0.21 (3.31)	--

Abbreviations: PDI, potential drug-drug interactions; PIM: potentially inappropriate medications

^*Models are adjusted for age, cancer type, gender, comorbidity, function, social support, and study arm

^**P<0.05

^***effect estimate is correlation coefficient