. Author manuscript; available in PMC: 2025 Jan 1.

Published in final edited form as: Mult Scler Relat Disord. 2023 Nov 18;81:105139. doi: 10.1016/j.msard.2023.105139

Table 3.

Hazard ratio for time to first CDP in EmBioProMS participants

Baseline PROMS	Whole EmBioProMS population		PPMS		SPMS
Baseline PROMS	HR [CI]	p	HR [CI]	p	HR [CI]	p
BDI-II (continuous)	1.00 [0.97 - 1.03]	0.783	1.01 [0.97 – 1.04]	0.693	0.98 [0.93 – 1.04]	0.600
BDI-II > 70^th percentile	0.80 [0.45 - 1.42]	0.447	0.74 [0.36 – 1.48]	0.391	0.63 [0.23 – 1.70]	0.361
BDI-II > 80^th percentile	1.09 [0.60 – 2.00]	0.776	0.94 [0.45 – 1.96]	0.879	0.55 [0.16 – 1.89]	0.347
BDI-II > 90^th percentile	1.45 [0.69 – 3.05]	0.328	1.34 [0.54 – 3.32]	0.522	0.96 [0.19 – 4.76]	0.962
MSIS-29 physical component (continuous)	1.01 [1.00 - 1.02]	0.066	1.03 [1.01 – 1.05]	0.002	1.00 [0.98 – 1.02]	0.919
MSIS-29_physical > 70^th percentile	1.76 [1.03 - 3.02]	0.039	3.72 [1.64 – 8.47]	0.002	1.50 [0.55 – 4.05]	0.427
MSIS-29_physical > 80^th percentile	1.76 [0.96 – 3.21]	0.066	6.86 [2.58 – 18.23]	<0.001	0.91 [0.31 – 2.66]	0.869
MSIS-29_physical > 90^th percentile	1.59 [0.78 – 3.21]	0.200	6.69 [2.12 – 21.11]	0.001	0.67 [0.20 – 2.30]	0.526
MSIS-29 psychological component (continuous)	1.01 [1.00 - 1.02]	0.034	1.02 [1.00 – 1.03]	0.009	0.99 [0.97 – 1.01]	0.567
MSIS-29_{psychological} > 70^th percentile	1.39 [0.83 - 2.33]	0.204	1.87 [0.93 – 3.76]	0.080	0.76 [0.28 – 2.02]	0.578
MSIS-29_{psychological} > 80^th percentile	1.40 [0.80 – 2.44]	0.238	2.51 [1.15– 5.46]	0.020	0.48 [0.15 – 1.52]	0.213
MSIS-29_{psychological} > 90^th percentile	1.28 [0.60 – 2.72]	0.524	3.38 [1.40 – 8.18]	0.007	0.27 [0.03 – 2.29]	0.228
FSMC (continuous)	1.00 [0.99 - 1.02]	0.962	1.01 [0.99 – 1.03]	0.396	1.00 [0.97 – 1.02]	0.748
FSMC > 70^th percentile	1.13 [0.66 - 1.95]	0.651	1.96 [0.93 – 4.12]	0.077	0.83 [0.32 – 2.14]	0.703
FSMC > 80^th percentile	1.12 [0.63 – 1.97]	0.704	3.14 [1.45 – 6.82]	0.004	0.51 [0.16 – 1.62]	0.254
FSMC > 90^th percentile	1.35 [0.67 – 2.73]	0.406	2.98 [1.02 – 8.71]	0.045	0.57 [0.17 – 1.91]	0.363

BDI-II: beck-depression inventory-II, MSIS-29: multiple sclerosis impact scale (physical, and psychological components), FSMC: fatigue scale for motor and cognition. HR: hazard ratio, CI: 95% confidence interval.