Figure 1.

Illustration for the identification of disease signal from high-throughput omics experiments. (A) High-throughput experimental approaches such as gene expression microarrays or quantitative proteomics generate GOIs (such as DEGs/proteins). (B) The volcano plot illustrates the distribution of GOIs. (C) Disease signals are the most promising, biologically plausible linkages between the known disease genes and GOIs. (D) Diffusion strategy was developed to reconstruct the gene distance in the PPI network by transition probability. (E) Embedding strategy was established to reconstruct the gene distance in the PPI network by embedding vector cosine similarity. (F) The underlying diseases knowledge base.