Table 2:
Case # | Component (predominant cell type) | CK7 | CK20 | ER | PR | Pax8 | CDX2 | MUC6 | WT1 | ARID1A | AB/PAS |
---|---|---|---|---|---|---|---|---|---|---|---|
MO-1 | Mucinous (intestinal>gastric) | +++ | ++ | − | − | − | ++ | + | − | Loss | neutral/acidic |
Mullerian (endometrioid) | +++ | − | +++ | +++ | ++ | − | − | + | Loss | No intracellular mucin | |
MO-2 | Mucinous (gastric) | +++ | + | − | − | + | − | − | − | Loss | Neutral |
Mullerian (endometrioid) | +++ | − | + | +++ | ++ | − | − | − | Subclonal loss | No intracellular mucin | |
MO-3 | Mucinous (gastric>intestinal) | +++ | ++ | − | − | ++ | ++ | − | − | Intact | Mixture (neutral>acidic) |
Mullerian (endometrioid/clear cell) | +++ | − | ++ | ++ | +++ | − | − | − | Intact | Only rare cells with mucin (acidic) | |
MO-4 | Mucinous (gastric>intestinal) | +++ | + | + | − | + | + | ++ | − | Loss | Mixture (neutral>acidic) |
Mullerian (endometrioid/clear cell) | +++ | − | ++ | − | ++ | − | − | − | Loss | No intracellular mucin |
Immunohistochemistry results reported as follows:
, negative;
, focal/weak positive;
moderate/patchy positive;
, strong/diffuse positive.