TABLE 1.
Virus titers in mouse brains following i.n. infection with CVS-F3
Mouse strain | Virus titer (FFU/g of brain)a at indicated days p.i.
|
|||||
---|---|---|---|---|---|---|
8
|
13
|
21
|
||||
1 | 2 | 1 | 2 | 1 | 2 | |
Rag-2 k.o. | 5.0 × 105 | 1.0 × 105 | 2.0 × 105 | 2.5 × 105 | 1.0 × 106 | 5.0 × 106 |
β2m k.o. | 7.5 × 103 | 1.8 × 104 | <10 | <10 | <10 | <10 |
JHD k.o. | 2.0 × 104 | 5.0 × 104 | 1.5 × 104 | 5.0 × 104 | 5.0 × 104 | 5.0 × 103 |
C3/C4 k.o. | 1.5 × 104 | 1.0 × 105 | <10 | <10 | <10 | <10 |
IFN-α/βR k.o. | 2.5 × 105 | 2.5 × 105 | <10 | <10 | <10 | <10 |
IFN-γR k.o. | 4.0 × 105 | 5.0 × 104 | <10 | <10 | <10 | <10 |
C57BL/6J | 1.0 × 105 | 1.5 × 105 | <10 | <10 | <10 | <10 |
129/SvEv | 7.5 × 103 | 2.6 × 103 | <10 | <10 | <10 | <10 |
Determined in two mice (1 and 2) for each time point and mouse strain.