| Parameters |
Groups |
P-value |
| Study group |
Control group |
| 100 Cases |
200 Adrenals |
20 Cases |
40 Adrenals |
| Capsular Haemorrhage |
Present |
98 (98%) |
196 (98%) |
8 (40%) |
13 (32.5%) |
<0.0001 |
| Absent |
2 (2%) |
4 (2%) |
12 (60%) |
27 (67.5%) |
| Nodular Hyperplasia |
Present |
48 (48%) |
90 (45%) |
4 (20%) |
8 (20%) |
0.026 |
| Absent |
52 (52%) |
110 (55%) |
16 (80%) |
32 (80%) |
| Histological Changes in Zona Glomerulosa |
Cell Size |
Normal |
Normal |
Normal |
- |
- |
| Zonal thinning with shrunken cells and increased nuclear density |
88 (88%) |
176 (88%) |
0 (0%) |
- |
| Nuclear prominence |
68 (68%) |
135 (67.5%) |
0 (0%) |
- |
| Sinusoidal dilatation |
98 (98%) |
195 (97.5%) |
0 (0%) |
- |
| Lipid depletion |
Not marked |
Not marked |
Not marked |
- |
| Parenchymal cord-like arrangement of cells |
Not marked |
Not marked |
Not marked |
- |
| Hemorrhage |
7 (7%) |
14 (7%) |
0 (0%) |
- |
| Hemorrhage + Hemosiderin-like pigments |
1 (1%) |
2 (1%) |
0 (0%) |
- |
| Edema |
4 (4%) |
8 (4%) |
0 (0%) |
- |
| Necrosis |
2 (2%) |
4 (2%) |
0 (0%) |
- |
| Edema + Necrosis |
2 (2%) |
4 (2%) |
0 (0%) |
- |
| Histological Changes in Zona Fasciculata |
Extension of Zona Fasciculata |
96 (96%) |
192 (96%) |
0 (0%) |
0 (0%) |
- |
| Cell size |
Normal |
Normal |
Normal |
Normal |
| Nuclear prominence |
95 (95%) |
189 (94.5%) |
0 (0%) |
0 (0%) |
| Sinusoidal dilatation |
99 (99%) |
197 (98.5%) |
0 (0%) |
0 (0%) |
| Focal lipid depletion |
53 (53%) |
102 (51%) |
9 (45%) |
17 (42.5%) |
| Diffuse lipid depletion |
47 (47%) |
94 (47%) |
0 (0%) |
0 (0%) |
| Focal parenchymal cord-like arrangement of cells |
53 (53%) |
102 (51%) |
0 (0%) |
0 (0%) |
| Diffuse parenchymal cord-like arrangement of cells |
46 (46%) |
92 (46%) |
0 (0%) |
0 (0%) |
| Hemorrhage |
8 (8%) |
14 (7%) |
0 (0%) |
0 (0%) |
| Hemorrhage + Hemosiderin-like pigments |
8 (8%) |
16 (8%) |
0 (0%) |
0 (0%) |
| Edema |
7 (7%) |
14 (7%) |
1 (5%) |
2 (5%) |
| Necrosis |
1 (1%) |
2 (1%) |
0 (0%) |
0 (0%) |
| Edema + Necrosis |
3 (3%) |
6 (3%) |
0 (0%) |
0 (0%) |
| Histological Changes in Zona Reticularis |
Extension of Zona Fasciculata |
92 (92%) |
182 (91%) |
0 (0%) |
0 (0%) |
- |
| Cell size |
Normal |
Normal |
Normal |
Normal |
| Nuclear prominence |
95 (95%) |
189 (92.5%) |
0 (0%) |
0 (0%) |
| Sinusoidal dilatation |
98 (98%) |
194 (97%) |
0 (0%) |
0 (0%) |
| Focal lipid depletion |
83 (83%) |
161 (80.5%) |
4 (20%) |
7 (17.5%) |
| Diffuse lipid depletion |
13 (13%) |
25 (12.5%) |
0 (0%) |
0 (0%) |
| Focal parenchymal cord-like arrangement of cells |
77 (77%) |
151 (75.5%) |
0 (0%) |
0 (0%) |
| Diffuse parenchymal cord-like arrangement of cells |
14 (14%) |
27 (13.5%) |
0 (0%) |
0 (0%) |
| Hemorrhage |
32 (32%) |
64 (32%) |
0 (0%) |
0 (0%) |
| Haemorrhage + Hemosiderin like pigments |
12 (12%) |
21 (10.5%) |
0 (0%) |
0 (0%) |
| Edema |
49 (49%) |
95 (47.5%) |
0 (0%) |
0 (0%) |
| Edema + Necrosis |
9 (9%) |
16 (8%) |
1 (5%) |
2 (5%) |
| Histological Changes in the Medulla |
Cell size |
Normal |
Normal |
Normal |
- |
- |
| Extension of medulla |
25 (25%) |
44 (22%) |
0 (0%) |
- |
| Nuclear prominence |
71 (71%) |
139 (69.5%) |
0 (0%) |
- |
| Sinusoidal dilatation |
99 (99%) |
195 (97.5%) |
0 (0%) |
- |
| Hemorrhage |
16 (16%) |
30 (15%) |
0 (0%) |
- |
| Edema |
19 (19%) |
35 (17.5%) |
0 (0%) |
- |
| Necrosis |
1 (1%) |
2 (1%) |
0 (0%) |
- |
