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Emerging targeted Lp(a) lowering therapies.
| Therapy | Mechanism of action | Modification | % Lp(a) reduction | Current clinical trial stage |
|---|---|---|---|---|
| Muvalaplin | Inhibits the assembly of Lp(a) | ~25–65% [17] | Phase 1 | |
| Pelacarsen | AntiSense Oligonucleotide (ASO) | N-acetyl galactosamine (GalNAc) | 35–80% [18] | Phase 3 |
| Olpasiran | Small interfering RNA (siRNA) | GalNAc | 70–100% [19] | Phase 3 |
| SLN360 | siRNA | GalNAc | 46–98% [20] | Phase 2 |
| Lepodisiran | siRNA | GalNAc | 41–97% [21] | Phase 2 |
