Table 2. Calculated Kd values of dihydrotetrabenazine (DTBZ) for various single-point mutants.
| Mutant | Kd (nM) |
|---|---|
| WT | 15±3 |
| N34A | ND |
| N34D | ND |
| N34Q | ND |
| N34T | ND |
| E127A | 15±6 |
| F135A | ND |
| R189A | ND |
| V232L | ND |
| E312Q | ND |
| W318A | ND |
| W318F | 24±16 |
| W318H | ND |
| W318R | ND |
| F429A | 7.7±0.6 |
| Y433A | ND |